Publication Name	World Journal of Ophthalmology
Manuscript ID	27376
Country	United States

Received	2016-05-26 17:35
Peer-Review Started	2016-05-26 18:51
To Make the First Decision	2016-07-04 15:48
Return for Revision	2016-07-05 13:37
Revised	2016-08-24 07:42
Second Decision	2016-08-30 12:01
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-09-08 16:37
Articles in Press	2016-09-08 16:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-09-19 11:30
Publish the Manuscript Online	2016-09-21 15:39

ISSN	2218-6239 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Pharmacology & Pharmacy
Manuscript Type	Basic Study
Article Title	Human ciliary muscle cell responses to kinins: Activation of ERK1/2 and pro-matrix metalloproteinases secretion
Manuscript Source	Unsolicited Manuscript
All Author List	Najam A Sharif, Rajkumar Patil, Linya Li and Shahid Husain
Funding Agency and Grant Number
Corresponding Author	Najam A Sharif, PhD, Pharmaceutical Research, Alcon Research, Ltd. (A Novartis Company), 6201 South Freeway, Fort Worth, TX 76134, United States. naji333sha@yahoo.com
Key Words	Extracellular signal-regulated kinase-1/2; Bradykinin; Ciliary muscle; Matrix metalloproteinases; B2-receptor
Core Tip	Bradykinin (BK), its peptide and non-peptide analogs and mimetic were potently and efficaciously able to stimulate extracellular signal-regulated kinase 1/2 phosphorylation in human ciliary muscle (h-CM) cells in vitro. Additionally, these agonists also induced the production and secretion of pro-matrix metalloproteinases in a prostaglandin-independent manner. Selective antagonists helped link these responses to be mediated via the B2-receptor sub-type in h-CM cells. These mechanistic studies show how BK can lower intraocular pressure in animals when delivered to the eye.
Publish Date	2016-09-21 15:39
Citation	Sharif NA, Patil R, Li L, Husain S. Human ciliary muscle cell responses to kinins: Activation of ERK1/2 and pro-matrix metalloproteinases secretion. World J Ophthalmol 2016; 6(3): 20-27
URL	http://www.wjgnet.com/2218-6239/full/v6/i3/20.htm
DOI	http://dx.doi.org/10.5318/wjo.v6.i3.20

Full Article (PDF)	WJO-6-20.pdf
Full Article (Word)	WJO-6-20.doc
Manuscript File	27376-Review.docx
Answering Reviewers	27376-Answering reviewers.pdf
Audio Core Tip	27376-Audio core tip.m4a
Biostatistics Review Certificate	27376-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	27376-Conflict-of-interest statement.pdf
Copyright License Agreement	27376-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	Grant_Application_Form_20160526173310.pdf
Institutional Animal Care and Use Committee Approval Form or Document	27376-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	27376-Institutional review board statement.pdf
Peer-review Report	27376-Peer-review(s).pdf
Scientific Misconduct Check	27376-Scientific misconduct check.pdf
Scientific Editor Work List	27376-Scientific editor work list.pdf