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Articles Published Processes
9/21/2016 3:39:00 PM | Browse: 1257 | Download: 2541
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Received |
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2016-05-26 17:35 |
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Peer-Review Started |
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2016-05-26 18:51 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2016-07-05 13:37 |
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Revised |
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2016-08-24 07:42 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2016-08-30 12:01 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2016-09-08 16:37 |
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Articles in Press |
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2016-09-08 16:37 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-09-19 11:30 |
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Publish the Manuscript Online |
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2016-09-21 15:39 |
| ISSN |
2218-6239 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Basic Study |
| Article Title |
Human ciliary muscle cell responses to kinins: Activation of ERK1/2 and pro-matrix metalloproteinases secretion
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Najam A Sharif, Rajkumar Patil, Linya Li and Shahid Husain |
| Funding Agency and Grant Number |
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| Corresponding Author |
Najam A Sharif, PhD, Pharmaceutical Research, Alcon Research, Ltd. (A Novartis Company), 6201 South Freeway, Fort Worth, TX 76134, United States. naji333sha@yahoo.com |
| Key Words |
Extracellular signal-regulated kinase-1/2; Bradykinin; Ciliary muscle; Matrix metalloproteinases; B2-receptor |
| Core Tip |
Bradykinin (BK), its peptide and non-peptide analogs and mimetic were potently and efficaciously able to stimulate extracellular signal-regulated kinase 1/2 phosphorylation in human ciliary muscle (h-CM) cells in vitro. Additionally, these agonists also induced the production and secretion of pro-matrix metalloproteinases in a prostaglandin-independent manner. Selective antagonists helped link these responses to be mediated via the B2-receptor sub-type in h-CM cells. These mechanistic studies show how BK can lower intraocular pressure in animals when delivered to the eye. |
| Publish Date |
2016-09-21 15:39 |
| Citation |
Sharif NA, Patil R, Li L, Husain S. Human ciliary muscle cell responses to kinins: Activation of ERK1/2 and pro-matrix metalloproteinases secretion. World J Ophthalmol 2016; 6(3): 20-27
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| URL |
http://www.wjgnet.com/2218-6239/full/v6/i3/20.htm |
| DOI |
http://dx.doi.org/10.5318/wjo.v6.i3.20 |
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