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11/26/2016 6:56:00 PM | Browse: 475 | Download: 845
Publication Name World Journal of Gastroenterology
Manuscript ID 27428
Country/Territory Spain
2016-05-29 12:55
Peer-Review Started
2016-05-30 09:39
To Make the First Decision
2016-08-08 09:08
Return for Revision
2016-08-08 11:24
2016-09-09 06:01
Second Decision
2016-09-30 17:37
Accepted by Journal Editor-in-Chief
2016-10-02 16:48
Accepted by Company Editor-in-Chief
2016-10-10 17:38
Articles in Press
2016-10-10 17:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-11-14 16:08
Publish the Manuscript Online
2016-11-26 18:57
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medicine, Research and Experimental
Manuscript Type Basic Study
Article Title Angiopoietin-2/angiopoietin-1 as non-invasive biomarker of cirrhosis in chronic hepatitis C
Manuscript Source Invited Manuscript
All Author List Ángel Hernández-Bartolomé, Rosario López-Rodríguez, María Jesús Borque, Leticia González-Moreno, Yolanda Real-Martínez, Luisa García-Buey, Ricardo Moreno-Otero and Paloma Sanz-Cameno
Funding Agency and Grant Number
Funding Agency Grant Number
Ministerio de Ciencia e Innovación (partially) SAF: 2010/21805
CIBERehd (Instituto de Salud Carlos III, Madrid) and Fundación Mutua Madrileña
Asociación Española Contra el Cáncer AIO 2010, AECC
Corresponding author Paloma Sanz-Cameno, PhD, Liver Unit, Gastroenterology Service, Instituto Investigación Sanitaria Princesa, IIS-IP, 28006 Madrid, Spain. paloma_march@hotmail.com
Keywords Chronic hepatitis C; Area under the curve of receiver operator characteristics; Liver fibrosis; Cirrhosis; Angiopoietin-2; Angiopoietin-1; Biomarker; Angiogenesis
Core Tip Chronic hepatitis C (CHC) is the leading cause of cirrhosis and hepatocellular carcinoma and monitoring of liver fibrosis is essential for the prognosis and treatment of these patients. Liver biopsy, the gold standard for fibrosis determination, is invasive and costly. Therefore, novel reliable non-invasive biomarkers are crucial for CHC management. Angiogenesis is closely related to the pathogenesis of the disease and angiopoietins play a relevant role in this process. Interestingly, this study confirms the valuable association of circulating angiopoitein-1 (Ang1) and angiopoitein-2 (Ang2) levels with CHC progression and reveals the outstanding role of Ang2/Ang1 ratio as potential non-invasive biomarker of cirrhosis.
Publish Date 2016-11-26 18:57
Citation Hernández-Bartolomé A, López-Rodríguez R, Borque MJ, González-Moreno L, Real-Martínez Y, García-Buey L, Moreno-Otero R, Sanz-Cameno P. Angiopoietin-2/angiopoietin-1 as non-invasive biomarker of cirrhosis in chronic hepatitis C. World J Gastroenterol 2016; 22(44): 9744-9751
Url http://www.wjgnet.com/1007-9327/full/v22/i44/9744.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i44.9744
Full Article (PDF) WJG-22-9744.pdf
Full Article (Word) WJG-22-9744.doc
Manuscript File 27428-Review.docx
Answering Reviewers 27428-Answering reviewers.pdf
Audio Core Tip 27428-Audio core tip.mp3
Biostatistics Review Certificate 27428-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 27428-Conflict of interest statement.pdf
Copyright License Agreement 27428-Copyright assignment.pdf
Data Sharing Statement 27428-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 27428-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 27428-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 27428-Language certificate.pdf
Scientific Research Process 27428-Scientific research process.pdf
Peer-review Report 27428-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 27428-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 27428-Scientific misconduct check.pdf
Scientific Editor Work List 27428-Scientific editor work list.pdf