Publication Name	World Journal of Gastroenterology
Manuscript ID	27428
Country	Spain

Received	2016-05-29 12:55
Peer-Review Started	2016-05-30 09:39
To Make the First Decision	2016-08-08 09:08
Return for Revision	2016-08-08 11:24
Revised	2016-09-09 06:01
Second Decision	2016-09-30 17:37
Accepted by Journal Editor-in-Chief	2016-10-02 16:48
Accepted by Executive Editor-in-Chief	2016-10-10 17:38
Articles in Press	2016-10-10 17:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-11-14 16:08
Publish the Manuscript Online	2016-11-26 18:57

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Medicine, Research & Experimental
Manuscript Type	Basic Study
Article Title	Angiopoietin-2/angiopoietin-1 as non-invasive biomarker of cirrhosis in chronic hepatitis C
Manuscript Source	Invited Manuscript
All Author List	Ángel Hernández-Bartolomé, Rosario López-Rodríguez, María Jesús Borque, Leticia González-Moreno, Yolanda Real-Martínez, Luisa García-Buey, Ricardo Moreno-Otero and Paloma Sanz-Cameno
Funding Agency and Grant Number	Funding Agency Grant Number Ministerio de Ciencia e Innovación (partially) SAF: 2010/21805 CIBERehd (Instituto de Salud Carlos III, Madrid) and Fundación Mutua Madrileña Asociación Española Contra el Cáncer AIO 2010, AECC
Corresponding Author	Paloma Sanz-Cameno, PhD, Liver Unit, Gastroenterology Service, Instituto Investigación Sanitaria Princesa, IIS-IP, 28006 Madrid, Spain. paloma_march@hotmail.com
Key Words	Chronic hepatitis C; Area under the curve of receiver operator characteristics; Liver fibrosis; Cirrhosis; Angiopoietin-2; Angiopoietin-1; Biomarker; Angiogenesis
Core Tip	Chronic hepatitis C (CHC) is the leading cause of cirrhosis and hepatocellular carcinoma and monitoring of liver fibrosis is essential for the prognosis and treatment of these patients. Liver biopsy, the gold standard for fibrosis determination, is invasive and costly. Therefore, novel reliable non-invasive biomarkers are crucial for CHC management. Angiogenesis is closely related to the pathogenesis of the disease and angiopoietins play a relevant role in this process. Interestingly, this study confirms the valuable association of circulating angiopoitein-1 (Ang1) and angiopoitein-2 (Ang2) levels with CHC progression and reveals the outstanding role of Ang2/Ang1 ratio as potential non-invasive biomarker of cirrhosis.
Publish Date	2016-11-26 18:57
Citation	Hernández-Bartolomé A, López-Rodríguez R, Borque MJ, González-Moreno L, Real-Martínez Y, García-Buey L, Moreno-Otero R, Sanz-Cameno P. Angiopoietin-2/angiopoietin-1 as non-invasive biomarker of cirrhosis in chronic hepatitis C. World J Gastroenterol 2016; 22(44): 9744-9751
URL	http://www.wjgnet.com/1007-9327/full/v22/i44/9744.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i44.9744

Full Article (PDF)	WJG-22-9744.pdf
Full Article (Word)	WJG-22-9744.doc
Manuscript File	27428-Review.docx
Answering Reviewers	27428-Answering reviewers.pdf
Audio Core Tip	27428-Audio core tip.mp3
Biostatistics Review Certificate	27428-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	27428-Conflict of interest statement.pdf
Copyright License Agreement	27428-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	27428-Grant application form(s).pdf
Institutional Review Board Approval Form or Document	27428-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	27428-Language certificate.pdf
Peer-review Report	27428-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	27428-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	27428-Scientific misconduct check.pdf
Scientific Editor Work List	27428-Scientific editor work list.pdf