Publication Name	World Journal of Stem Cells
Manuscript ID	27458
Country	Japan

Received	2016-05-30 17:02
Peer-Review Started	2016-06-03 10:02
To Make the First Decision	2016-07-05 12:24
Return for Revision	2016-07-14 20:45
Revised	2016-07-22 07:54
Second Decision	2016-09-12 09:59
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-09-22 14:28
Articles in Press	2016-09-22 14:28
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-11-15 08:22
Publish the Manuscript Online	2016-11-21 07:57

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Gene expression and pathway analysis of CTNNB1 in cancer and stem cells
Manuscript Source	Invited Manuscript
All Author List	Shihori Tanabe, Takeshi Kawabata, Kazuhiko Aoyagi, Hiroshi Yokozaki and Hiroki Sasaki
Funding Agency and Grant Number
Corresponding Author	Shihori Tanabe, PhD, Division of Risk Assessment, National Institute of Health Sciences, 1-18-1, Kami-yoga, Setagaya-ku, Tokyo 158-8501, Japan. stanabe@nihs.go.jp
Key Words	Beta-catenin; CTNNB1; Epithelial-mesenchymal transition; Mesenchymal stem cell; Stem cell
Core Tip	Beta-catenin signaling consists of several pathway cascades, such as those that are involved in pluripotent stem cell generation and cancer. Several genes, including EPHA8, SS18, ICE1, PTCH1, MSH3 and CARD11, are mutated along with CTNNB1. The expression of the CTNNB1, CDH1, MYC, LEF1 and TCF7L2 genes, which are related to the CTNNB1 network, is up-regulated in diffuse-type GC cells compared to MSCs. 3D complex structures for beta-catenin (CTNB1_HUMAN) with LEF_MOUSE and TF7L2_HUMAN were found using the HOMCOS database. The EMT-related gene CTNNB1 plays an important role in pluripotent stem cell signaling and cancer signaling.
Publish Date	2016-11-21 07:57
Citation	Tanabe S, Kawabata T, Aoyagi K, Yokozaki H, Sasaki H. Gene expression and pathway analysis of CTNNB1 in cancer and stem cells. World J Stem Cells 2016; 8(11): 384-395
URL	http://www.wjgnet.com/1948-0210/full/v8/i11/384.htm
DOI	http://dx.doi.org/10.4252/wjsc.v8.i11.384

Full Article (PDF)	WJSC-8-384.pdf
Full Article (Word)	WJSC-8-384.doc
Manuscript File	27458-Review.doc
Answering Reviewers	27458-Answering reviewers.pdf
Audio Core Tip	27458-Audio core tip.mp3
Biostatistics Review Certificate	27458-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	27458-Conflict-of-interest statement.pdf
Copyright License Agreement	27458-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	27458-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	27458-Language certificate.pdf
Peer-review Report	27458-Peer-review(s).pdf
Scientific Misconduct Check	27458-Scientific misconduct check.pdf
Scientific Editor Work List	27458-Scientific editor work list.pdf