Publication Name	World Journal of Radiology
Manuscript ID	27497
Country	Japan

Received	2016-06-01 08:30
Peer-Review Started	2016-06-09 16:41
First Decision by Editorial Office Director
Return for Revision	2016-07-30 15:21
Revised	2016-08-08 23:47
Publication Fee Transferred
Second Decision by Editor	2016-09-05 09:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2016-09-18 14:30
Articles in Press	2016-09-18 14:30
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-11-16 12:26
Publish the Manuscript Online	2016-11-21 08:10

ISSN	1949-8470 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Nuclear Science & Technology
Manuscript Type	Minireviews
Article Title	Mechanisms underlying 18F-fluorodeoxyglucose accumulation in colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Kenji Kawada, Masayoshi Iwamoto and Yoshiharu Sakai
Funding Agency and Grant Number
Corresponding Author	Kenji Kawada, MD, PhD, Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin- Kawara-cho, Sakyo-ku, Kyoto 606-8507, Japan. kkawada@kuhp.kyoto-u.ac.jp
Key Words	18F-fluorodeoxyglucose-positron emission tomography; Colorectal cancer; Glucose metabolism; Mutational status; KRAS
Core Tip	Malignant cancers are preferential to metabolize glucose by glycolysis, even in the presence of oxygen, so-called Warburg effect. This elevated glucose metabolism is responsible for 18F-fluorodeoxyglucose (FDG) accumulation into cancer cells, which results in the positive signals in FDG-positron emission tomography scans. In spite of its clinical utility, the cellular and molecular mechanisms of 18F-FDG accumulation have not yet been elucidated. Here we review the current literature published with respect to the mechanisms of 18F-FDG accumulation into colorectal cancer tissues.
Publish Date	2016-11-21 08:10
Citation	Kawada K, Iwamoto M, Sakai Y. Mechanisms underlying 18F-fluorodeoxyglucose accumulation in colorectal cancer. World J Radiol 2016; 8(11): 880-886
URL	http://www.wjgnet.com/1949-8470/full/v8/i11/880.htm
DOI	http://dx.doi.org/10.4329/wjr.v8.i11.880

Full Article (PDF)	WJR-8-880.pdf
Full Article (Word)	WJR-8-880.doc
Manuscript File	27497-Review.docx
Answering Reviewers	27497-Answering reviewers.pdf
Audio Core Tip	27497-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	27497-Conflict-of-interest statement.pdf
Copyright License Agreement	27497-Copyright assignment.PDF
Supplementary Material	Supplementary_Material_20160601004100.doc
Peer-review Report	27497-Peer-review(s).pdf
Scientific Misconduct Check	27497-Scientific misconduct check.pdf
Scientific Editor Work List	27497-Scientific editor work list.pdf