Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	27523
Country	United States

Received	2016-06-02 08:39
Peer-Review Started	2016-06-06 10:46
To Make the First Decision	2016-09-02 14:06
Return for Revision	2016-09-13 10:11
Revised	2016-10-01 04:25
Second Decision	2016-12-20 15:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-01-03 15:07
Articles in Press	2017-01-03 15:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-03-07 09:27
Publish the Manuscript Online	2017-03-09 16:18

ISSN	1948-5204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Mathematical & Computational Biology
Manuscript Type	Frontier
Article Title	CpG island methylator phenotype in adenocarcinomas from the digestive tract: Methods, conclusions, and controversies
Manuscript Source	Invited Manuscript
All Author List	Francisco Sánchez-Vega, Valer Gotea, Yun-Ching Chen and Laura Elnitski
Funding Agency and Grant Number
Corresponding Author	Laura Elnitski, PhD, Senior Investigator, Head, Genomic Functional Analysis Section, National Human Genome Research Institute, National Institutes of Health, 5625 Fishers Lane, Rockville, MD 20852, United States. elnitski@mail.nih.gov
Key Words	CpG island methylator phenotype; CpG island; Promoter; DNA methylation; Hypermethylation; Gastrointestinal cancer
Core Tip	Awareness of the CpG island methylator phenotype (CIMP) is growing for all adenocarcinomas. Here, we summarize previous work on the topic and discuss unanswered questions regarding commonalities and differences of CIMP tumors from esophageal, gastric, and colorectal adenocarcinomas, where data has been made available from the Cancer Genome Atlas. Our analysis includes a review of our pan-cancer method to stratify tumors based on CIMP and addresses the most frequent mutations found in those samples. We include new data implicating truncating mutations in RNF43 and silencing of WIF1I. We also describe in detail the methylation of CpG sites within the MLH1 promoter across these tumor types.
Publish Date	2017-03-09 16:18
Citation	Sánchez-Vega F, Gotea V, Chen YC, Elnitski L. CpG island methylator phenotype in adenocarcinomas from the digestive tract: Methods, conclusions, and controversies. World J Gastrointest Oncol 2017; 9(3): 105-120
URL	http://www.wjgnet.com/1948-5204/full/v9/i3/105.htm
DOI	http://dx.doi.org/10.4251/wjgo.v9.i3.105

Full Article (PDF)	WJGO-9-105.pdf
Full Article (Word)	WJGO-9-105.doc
Manuscript File	27523-Review.docx
Answering Reviewers	27523-Answering reviewers.pdf
Audio Core Tip	27523-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	27523-Conflict-of-interest statement.pdf
Copyright License Agreement	27523-Copyright assignment.pdf
Peer-review Report	27523-Peer-review(s).pdf
Scientific Misconduct Check	27523-Scientific misconduct check.pdf
Scientific Editor Work List	27523-Scientific editor work list.pdf