Publication Name	World Journal of Gastroenterology
Manuscript ID	2753
Country	China

Received	2013-03-12 09:53
Peer-Review Started	2013-03-12 19:25
First Decision by Editorial Office Director
Return for Revision	2013-05-24 17:08
Revised	2013-06-11 09:17
Publication Fee Transferred
Second Decision by Editor	2013-07-18 15:14
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2013-07-19 03:49
Articles in Press
Edit the Manuscript by Language Editor	2013-08-03 19:11
Typeset the Manuscript	2013-08-14 18:29
Publish the Manuscript Online	2013-09-09 09:30

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Hypermethylation of TGF-β1 gene promoter in gastric cancer
Manuscript Source	Invited Manuscript
All Author List	Yong-Qi Wang, Yu-Min Li, Xun Li, Tao Liu, Xiao-Kang Liu, Jun-Qiang Zhang, Ju-Wu Guo, Ling-Yun Guo and Liang Qiao
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 31270532 Foundation of Key Laboratory of Digestive System Tumors of Gansu Province and the Fundamental Research Funds for the Central Universities lzujbky-2011-t03-03
Corresponding Author	Yu-Min Li, MD, PhD, Professor, School of Life Sciences, Lanzhou University, No. 222 Tianshui South Road, Lanzhou 730000, Gansu Province, China. liym@lzu.edu.cn
Key Words	Transforming growth factor-β1; Interleukin-1β; Methylation; Helicobacter pylori; Gastric cancer
Core Tip	In vitro studies showed that GES-1 cells exposed to Helicobacter pylori (H. pylori) did not show significant transforming growth factor-β1 (TGF-β1) methylation. However, treatment of the GES-1 cells with interleukin (IL)-1β led to a dose-dependent methylation of TGF-β1, which was partially abolished by IL-1RA. The high levels of TGF-β1 promoter methylation in H. pylori positive patients was likely the result of H. pylori-induced inflammation rather than H. pylori itself. IL-1β may be an important mediator for H. pylori-induced gene methylation during gastric cancer development.
Publish Date	2013-09-09 09:30
Citation	Wang YQ, Li YM, Li X, Liu T, Liu XK, Zhang JQ, Guo JW, Guo LY, Qiao L. Hypermethylation of TGF-β1 gene promoter in gastric cancer. World J Gastroenterol 2013; 19(33): 5557-5564
URL	http://www.wjgnet.com/1007-9327/full/v19/i33/5557.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i33.5557

Full Article (PDF)	WJG-19-5557.pdf
Manuscript File	2753-Review.doc
Answering Reviewers	2753-Answering reviewers.pdf
Copyright License Agreement	2753-Copyright assignment.doc
Non-Native Speakers of English Editing Certificate	2753-Language certificate.pdf
Peer-review Report	2753-Peer review(s).pdf
Scientific Editor Work List	2753-Scientific editor work list.doc