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Articles Published Processes
10/12/2016 2:18:00 PM | Browse: 790 | Download: 1738
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Received |
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2016-06-04 14:36 |
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Peer-Review Started |
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2016-06-04 21:00 |
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To Make the First Decision |
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2016-07-12 09:21 |
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Return for Revision |
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2016-07-15 15:34 |
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Revised |
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2016-07-27 00:44 |
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Second Decision |
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2016-08-17 09:35 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-08-19 09:22 |
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Articles in Press |
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2016-08-19 09:22 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2016-08-30 15:58 |
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Typeset the Manuscript |
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2016-09-29 11:37 |
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Publish the Manuscript Online |
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2016-10-12 14:18 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Embryonic liver fordin is involved in glucose glycolysis of hepatic stellate cell by regulating PI3K/Akt signaling
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wei Tu, Jin Ye and Zhi-Jun Wang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81300329 |
| National Natural Science Foundation of China |
81401992 |
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| Corresponding Author |
Zhi-Jun Wang, MD, PhD, Department of Gastroenterology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, 1277 Jiefang Road, Jianghan District, Wuhan 430022, Hubei Province, China. xhwzj@aliyun.com |
| Key Words |
Liver fibrosis; Embryonic liver fordin; PI3K/Akt signaling; Hepatic stellate cells; Glucose glycolysis |
| Core Tip |
The metabolism of activated hepatic stellate cells (HSCs) was reprogrammed. Silence of embryonic liver fordin (ELF) led to the inhibition of PI3K/Akt signaling and decrease of glycolysis in activated HSCs. Glucose glycolysis of activated HSCs was regulated by ELF through PI3K/Akt signaling The present study indicated that metabolism of HSCs may be a novel target for the diagnosis and treatment of liver cirrhosis in clinical practice. |
| Publish Date |
2016-10-12 14:18 |
| Citation |
Tu W, Ye J, Wang ZJ. Embryonic liver fordin is involved in glucose glycolysis of hepatic stellate cell by regulating PI3K/Akt signaling. World J Gastroenterol 2016; 22(38): 8519-8527 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i38/8519.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i38.8519 |
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