Publication Name	World Journal of Gastroenterology
Manuscript ID	2762
Country	China

Received	2013-03-13 08:52
Peer-Review Started	2013-03-13 19:42
To Make the First Decision	2013-04-16 09:21
Return for Revision	2013-04-20 20:52
Revised	2013-05-29 18:39
Second Decision	2013-07-18 15:14
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-07-19 03:51
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-08-07 17:03
Publish the Manuscript Online	2013-08-27 16:46

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Efficacy profiles for different concentrations of Lactobacillus acidophilus in experimental colitis
Manuscript Source	Invited Manuscript
All Author List	Lin-Lin Chen, Yi-You Zou, Fang-Gen Lu, Fu-Jun Li and Guang-Hui Lian
Funding Agency and Grant Number
Corresponding Author	Lin-Lin Chen, MD, Department of Gastroenterology, Xiangya Hospital of Central South University, Kaifu District, No. 87 Xiangya Road, Changsha 410008, Hunan Province, China. chenlinlinmedical@gmail.com
Key Words	Lactobacillus acidophilus; Bifidobacterium; Colonic flora; Therapeutic dose; Experimental colitis; Efficacy profile
Core Tip	Efficacies of the current treatments for ulcerative colitis (UC) are limited by procedure-related complications, poor patient compliance, and high relapse rates. Administration of supplemental probiotics represents a promising new therapy of UC. Since UC pathogenic sites mainly involve the rectum and colon and UC patients show differential composition profiles of intestinal bacteria, this study was designed to evaluate the therapeutic efficacies of various concentrations for the standard probiotic, Lactobacillus acidophilus, using a well-known murine model of experimental colitis to examine the changes in colitis symptoms and the corresponding effects on the bacterial flora in the distal and proximal colon.
Publish Date	2013-08-27 16:46
Citation	Chen LL, Zou YY, Lu FG, Li FJ, Lian GH. Efficacy profiles for different concentrations of Lactobacillus acidophilus in experimental colitis. World J Gastroenterol 2013; 19(32): 5347-5356
URL	http://www.wjgnet.com/1007-9327/full/v19/i32/5347.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i32.5347

Full Article (PDF)	WJG-19-5347.pdf
Manuscript File	2762-Review.doc
Answering Reviewers	2762-Answering reviewers.pdf
Copyright License Agreement	2762-Copyright assignment.doc
Non-Native Speakers of English Editing Certificate	2762-Language certificate.pdf
Peer-review Report	2762-Peer review(s).pdf
Scientific Editor Work List	2762-Scientific editor work list.doc