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1/20/2017 4:40:00 PM | Browse: 462 | Download: 433
Publication Name World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID 27626
Country of Manuscript Source United States
Received
2016-06-08 09:17
Peer-Review Started
2016-06-13 18:30
To Make the First Decision
2016-07-20 16:51
Return for Revision
2016-07-22 18:40
Revised
2016-07-23 05:46
Second Decision
2016-08-08 15:19
Accepted by Journal Editor-in-Chief
2016-08-09 06:01
Accepted by Company Editor-in-Chief
2016-08-16 13:58
Articles in Press
2016-08-16 13:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-01-12 17:22
Publish the Manuscript Online
2017-01-20 16:40
ISSN 2150-5349 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Review
Article Title Pathogenic mechanisms of pancreatitis
Manuscript Source Unsolicited Manuscript
All Author List Murli Manohar, Alok Kumar Verma, Sathisha Upparahalli Venkateshaiah, Nathan L Sanders and Anil Mishra
Funding Agency and Grant Number
Funding Agency Grant Number
National Institutes of Health R01 DK067255
National Institutes of Health R01 AI080581
Corresponding author Anil Mishra, PhD, Endowed Chair and Professor of Medicine, Department of Medicine, Section of Pulmonary Diseases, Tulane Eosinophilic Disorders Center, Tulane University School of Medicine, SL-9, 1430, Tulane Avnue, New Orleans, LA 70112, United States. amishra@tulane.edu
Keywords Pancreatitis; Pancreatic stellate cells; Transforming growth factor-β/SMAD; Janus kinase/signal transducers and activators; Mitogen-activated protein kinases
Core Tip Pancreatitis is an acute or chronic inflam-matory disease of the pancreas and characterized by destruction of acinar cells, which lead activation of several inflammatory cells like macrophages and granulocytes which secrete number of pro-inflammatory cytokines. These pro-inflammatory cytokines activate pancreatic stellate cells, i.e., the key cells of pancreatic fibrosis. Various molecular signaling pathways (i.e., transforming growth factor-β/SMAD, mitogen-activated protein kinases, Rho kinase, Janus kinase/signal transducers and activators, and phosphatidylinositol 3 kinase) are known to have critical role in the activation of pancreatic stellate cells in chronic pancreatitis and development of pancreatic fibrosis that lead to the pancreatic carcinoma.
Publish Date 2017-01-20 16:40
Citation Manohar M, Verma AK, Venkateshaiah SU, Sanders NL, Mishra A. Pathogenic mechanisms of pancreatitis. World J Gastrointest Pharmacol Ther 2017; 8(1): 10-25
Url http://www.wjgnet.com/2150-5349/full/v8/i1/10.htm
DOI http://dx.doi.org/10.4292/wjgpt.v8.i1.10
Full Article (PDF) WJGPT-8-10.pdf
Full Article (Word) WJGPT-8-10.doc
Manuscript File 27626-Review.doc
Answering Reviewers 27626-Answering reviewers.pdf
Audio Core Tip 27626-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 27626-Conflict-of-interest statement.pdf
Copyright License Agreement 27626-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 27626-Grant application form(s).pdf
Peer-review Report 27626-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 27626-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 27626-Scientific misconduct check.pdf
Scientific Editor Work List 27626-Scientific editor work list.pdf