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Articles Published Processes
1/20/2017 4:40:00 PM | Browse: 1434 | Download: 1828
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Received |
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2016-06-08 09:17 |
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Peer-Review Started |
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2016-06-13 18:30 |
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To Make the First Decision |
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2016-07-20 16:51 |
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Return for Revision |
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2016-07-22 18:40 |
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Revised |
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2016-07-23 05:46 |
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Second Decision |
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2016-08-08 15:19 |
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Accepted by Journal Editor-in-Chief |
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2016-08-09 06:01 |
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Accepted by Executive Editor-in-Chief |
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2016-08-16 13:58 |
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Articles in Press |
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2016-08-16 13:59 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-01-12 17:22 |
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Publish the Manuscript Online |
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2017-01-20 16:40 |
| ISSN |
2150-5349 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Pathogenic mechanisms of pancreatitis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Murli Manohar, Alok Kumar Verma, Sathisha Upparahalli Venkateshaiah, Nathan L Sanders and Anil Mishra |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Institutes of Health |
R01 DK067255 |
| National Institutes of Health |
R01 AI080581 |
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| Corresponding Author |
Anil Mishra, PhD, Endowed Chair and Professor of Medicine, Department of Medicine, Section of Pulmonary Diseases, Tulane Eosinophilic Disorders Center, Tulane University School of Medicine, SL-9, 1430, Tulane Avnue, New Orleans, LA 70112, United States. amishra@tulane.edu
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| Key Words |
Pancreatitis; Pancreatic stellate cells; Transforming growth factor-β/SMAD; Janus kinase/signal transducers and activators; Mitogen-activated protein kinases |
| Core Tip |
Pancreatitis is an acute or chronic inflam-matory disease of the pancreas and characterized by destruction of acinar cells, which lead activation of several inflammatory cells like macrophages and granulocytes which secrete number of pro-inflammatory cytokines. These pro-inflammatory cytokines activate pancreatic stellate cells, i.e., the key cells of pancreatic fibrosis. Various molecular signaling pathways (i.e., transforming growth factor-β/SMAD, mitogen-activated protein kinases, Rho kinase, Janus kinase/signal transducers and activators, and phosphatidylinositol 3 kinase) are known to have critical role in the activation of pancreatic stellate cells in chronic pancreatitis and development of pancreatic fibrosis that lead to the pancreatic carcinoma.
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| Publish Date |
2017-01-20 16:40 |
| Citation |
Manohar M, Verma AK, Venkateshaiah SU, Sanders NL, Mishra A. Pathogenic mechanisms of pancreatitis. World J Gastrointest Pharmacol Ther 2017; 8(1): 10-25 |
| URL |
http://www.wjgnet.com/2150-5349/full/v8/i1/10.htm |
| DOI |
http://dx.doi.org/10.4292/wjgpt.v8.i1.10 |
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