Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	27633
Country	Italy

Received	2016-06-08 16:07
Peer-Review Started	2016-06-14 12:05
To Make the First Decision	2016-07-25 12:03
Return for Revision	2016-07-29 15:35
Revised	2016-08-06 00:19
Second Decision	2016-09-22 08:17
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-10-09 10:48
Articles in Press	2016-10-09 10:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-10-26 15:19
Publish the Manuscript Online	2016-11-07 10:11

ISSN	2219-2808 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Pediatrics
Manuscript Type	Retrospective Cohort Study
Article Title	Serial physical examinations, a simple and reliable tool for managing neonates at risk for early-onset sepsis
Manuscript Source	Invited Manuscript
All Author List	Alberto Berardi, Anna Maria Buffagni, Cecilia Rossi, Eleonora Vaccina, Chiara Cattelani, Lucia Gambini, Federica Baccilieri, Francesca Varioli and Fabrizio Ferrari
Funding Agency and Grant Number
Corresponding Author	Alberto Berardi, MD, Neonatal Intensive Care Unit, Department of Mother and Child, Policlinic University Hospital, Avenue del Pozzo, 71, 41124 Modena, Italy. berardi.alberto@policlinico.mo.it
Key Words	Sepsis; Group B streptococcus; Intrapartum antibiotic prophylaxis; Newborn; Prevention
Core Tip	The management of asymptomatic neonates at-risk for early-onset sepsis (EOS) remains a challenge. Algorithms based on the threshold values of risk factors result in a large number of uninfected newborns being evaluated and treated. In a 4-mo, multicenter retro-spective cohort study, we evaluated a strategy based on serial physical examinations (SPEs) instead of sepsis workup. We studied 2092 neonates. Among 216 neonates initially managed through SPEs, only 12 (5.6%) had subsequently a sepsis workup; only 4 (1.9%) were given empirical antibiotics. All neonates had a normal outcome. SPEs is a simple and reliable tool for managing neonates at risk for EOS.
Publish Date	2016-11-07 10:11
Citation	Berardi A, Buffagni AM, Rossi C, Vaccina E, Cattelani C, Gambini L, Baccilieri F, Varioli F, Ferrari F. Serial physical examinations, a simple and reliable tool for managing neonates at risk for early-onset sepsis. World J Clin Pediatr 2016; 5(4): 358-364
URL	http://www.wjgnet.com/2219-2808/full/v5/i4/358.htm
DOI	http://dx.doi.org/10.5409/wjcp.v5.i4.358

Full Article (PDF)	WJCP-5-358.pdf
Full Article (Word)	WJCP-5-358.doc
Manuscript File	27633-Review.doc
Answering Reviewers	27633-Answering reviewers.pdf
Audio Core Tip	27633-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	27633-Conflict-of-interest statement.pdf
Copyright License Agreement	27633-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	27633-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	27633-Language certificate.pdf
Peer-review Report	27633-Peer-review(s).pdf
Scientific Misconduct Check	27633-Scientific misconduct check.pdf
Scientific Editor Work List	27633-Scientific editor work list.pdf