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Articles Published Processes
3/24/2017 9:18:00 AM | Browse: 698 | Download: 1018
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Received |
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2016-06-11 11:04 |
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Peer-Review Started |
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2016-06-13 19:53 |
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To Make the First Decision |
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2016-07-20 16:47 |
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Return for Revision |
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2016-07-22 19:10 |
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Revised |
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2016-08-02 21:54 |
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Second Decision |
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2016-12-07 16:34 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2016-12-14 16:44 |
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Articles in Press |
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2016-12-14 16:44 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2016-12-23 19:04 |
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Typeset the Manuscript |
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2017-03-06 18:22 |
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Publish the Manuscript Online |
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2017-03-24 09:18 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Observational Study |
| Article Title |
Characteristics of escape mutations from occult hepatitis B virus infected patients with hematological malignancies in South Egypt
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Abeer Elkady, Sayuki Iijima, Sahar Aboulfotuh, Elsayed Mostafa Ali, Douaa Sayed, Nashwa M Abdel-Aziz, Amany M Ali, Shuko Murakami, Masanori Isogawa and Yasuhito Tanaka |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Grant-in-Aid form Japan Society for the Promotion of Science |
15H05289 |
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| Corresponding Author |
Yasuhito Tanaka, MD, PhD, Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, 467-8601 Kawasumi, Mizuho, Nagoya 467-8601, Japan. ytanaka@med.nagoya-cu.ac.jp |
| Key Words |
Occult hepatitis B infection; Hematological malignancies; Escape mutation |
| Core Tip |
The present study was conducted to investigate the prevalence and virological characteristics of occult hepatitis B virus (HBV) infections in patients with hema-tological malignancies in Egypt. Serum samples were collected from 165 patients with different hematological malignancies and screened for occult HBV infection. In the present study, occult HBV infection was detected in 23 (42.6%) of 54 patients with hematological malignancies who were hepatitis B surface antigen (HBsAg) negative, but antibodies to HBV core (anti-HBc) positive. Based on in vitro study of clones inserted with 120T and 143L, it was found that the 120T mutation could impair HBsAg detection by changing its conformation. Patients with hematological malignancies should be screened and closely monitored for anti-HBc and HBV DNA. |
| Publish Date |
2017-03-24 09:18 |
| Citation |
Elkady A, Iijima S, Aboulfotuh S, Mostafa Ali E, Sayed D, Abdel-Aziz NM, Ali AM, Murakami S, Isogawa M, Tanaka Y. Characteristics of escape mutations from occult hepatitis B virus infected patients with hematological malignancies in South Egypt. World J Hepatol 2017; 9(9): 477-486 |
| URL |
http://www.wjgnet.com/1948-5182/full/v9/i9/477.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v9.i9.477 |
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