Publication Name	World Journal of Gastroenterology
Manuscript ID	27643
Country	China

Received	2016-06-09 15:52
Peer-Review Started	2016-06-13 19:35
First Decision by Editorial Office Director
Return for Revision	2016-08-02 10:13
Revised	2016-08-15 00:45
Publication Fee Transferred
Second Decision by Editor	2016-09-30 10:50
Second Decision by Editor-in-Chief	2016-10-03 09:05
Final Decision by Editorial Office Director	2016-10-10 17:14
Articles in Press	2016-10-10 17:14
Edit the Manuscript by Language Editor	2016-11-14 14:24
Typeset the Manuscript	2016-12-02 19:36
Publish the Manuscript Online	2016-12-13 00:40

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Pharmacology & Pharmacy
Manuscript Type	Basic Study
Article Title	Hepatoprotective and antioxidant effects of lycopene on non-alcoholic fatty liver disease in rat
Manuscript Source	Unsolicited Manuscript
All Author List	Wei Jiang, Mei-Hua Guo and Xin Hai
Funding Agency and Grant Number
Corresponding Author	Xin Hai, PhD, Pharmacy Department, First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China. hai_xin@163.com
Key Words	Lycopene; Antioxidant; Hepatoprotective; Non-alcoholic fatty liver; Cytochrome P450 2E1
Core Tip	Lycopene (Ly), a phytochemical belonging to the carotenoid family, is a red-colored pigment, apolar and acyclic carotenoid. The present study was designed to evaluate the possible hepatoprotective effect of Ly on non-alcoholic fatty liver disease (NAFLD) in rat. This study represents the first examination of the effects of Ly on the therapy of NAFLD, and showed down-regulated expression of TNF-α and indicated that CYP2E1 may be one of the action mechanisms for Ly.
Publish Date	2016-12-13 00:40
Citation	Jiang W, Guo Mh, Hai X. Hepatoprotective and antioxidant effects of lycopene on non-alcoholic fatty liver disease in rat. World J Gastroenterol 2016; 22(46): 10180-10188
URL	http://www.wjgnet.com/1007-9327/full/v22/i46/10180.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i46.10180

Full Article (PDF)	WJG-22-10180.pdf
Full Article (Word)	WJG-22-10180.doc
Manuscript File	27643-Review.docx
Answering Reviewers	27643-Answering reviewers.pdf
Audio Core Tip	27643-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	27643-Conflict-of-interest statement.pdf
Copyright License Agreement	27643-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	27643-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	27643-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	27643-Language certificate.pdf
Peer-review Report	27643-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	27643-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	27643-Scientific misconduct check.pdf
Scientific Editor Work List	27643-Scientific editor work list.pdf