Publication Name	World Journal of Stem Cells
Manuscript ID	27675
Country	Czech Republic

Received	2016-06-11 11:22
Peer-Review Started	2016-06-17 12:03
To Make the First Decision	2016-07-04 16:04
Return for Revision	2016-07-11 11:30
Revised	2016-07-27 06:37
Second Decision	2016-09-12 09:54
Accepted by Journal Editor-in-Chief	2016-09-13 11:31
Accepted by Executive Editor-in-Chief	2016-09-22 14:45
Articles in Press	2016-09-22 14:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-12-13 15:59
Publish the Manuscript Online	2016-12-19 15:23

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Medicine, Research & Experimental
Manuscript Type	Review
Article Title	Involvement of blood mononuclear cells in the infertility, age-associated diseases and cancer treatment
Manuscript Source	Invited Manuscript
All Author List	Antonin Bukovsky
Funding Agency and Grant Number
Corresponding Author	Antonin Bukovsky, MD, PhD, DSc, Professor, Laboratory of Reproductive Biology BIOCEV, Institute of Biotechnology Czech Academy of Sciences, Národní 3, 117 20 Praha 1, 25250 Vestec, Czech Republic. kamarhkq@gmail.com
Key Words	Blood mononuclear cells; Age-associated diseases; Infertility treatment; Regenerative medicine; Transfusion morphostatic treatment; Stem cells; Tissue control system; Immune system; Tissue morphostasis; Cancer immunotherapy
Core Tip	Currently, there are little possibilities to treat age-associated disorders, since the morphostasis of normal tissues and its alteration with age advancement remain poorly understood. The components of the immune system, beside immunity, exhibit an important morphostatic function in the regulation of tissue phy-siology and regeneration as participants in the tissue morphostasis management. Age-induced immune system decline is accompanied by gonadal infertility and growing incidence of age-associated diseases and cancers. Utili-zation of young blood can alleviate aging, and a novel simple elaborated immunotherapy can cause regression of advanced cancers without a need of the debulking surgery and/or exhaustive chemotherapy.
Publish Date	2016-12-19 15:23
Citation	Bukovsky A. Involvement of blood mononuclear cells in the infertility, age-associated diseases and cancer treatment. World J Stem Cells 2016; 8(12): 399-427
URL	http://www.wjgnet.com/1948-0210/full/v8/i12/399.htm
DOI	http://dx.doi.org/10.4252/wjsc.v8.i12.399

Full Article (PDF)	WJSC-8-399.pdf
Full Article (Word)	WJSC-8-399.doc
Manuscript File	27675-Review.doc
Answering Reviewers	27675-Answering reviewers.pdf
Audio Core Tip	27675-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	27675-Conflict-of-interest statement.pdf
Copyright License Agreement	27675-Copyright assignment.pdf
Peer-review Report	27675-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	27675-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	27675-Scientific misconduct check.pdf
Scientific Editor Work List	27675-Scientific editor work list.pdf