ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Article Reprints |
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Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Retrospective Study |
Article Title |
Diabetes mellitus may affect the long-term survival of hepatitis B virus-related hepatocellular carcinoma patients after liver transplantation
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Qing Zhang, Yong-Lin Deng, Chang Liu, Li-Hong Huang, Lei Shang, Xin-Guo Chen, Le-Tian Wang, Jin-Zan Du, Ying Wang, Pei-Xiao Wang, Hui Zhang and Zhong-Yang Shen |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
National Natural Science Foundation of China, General Program |
81372595 |
National High Technology Research and Development Program of China (863 Program) |
2012AA021006 |
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Corresponding Author |
Dr. Zhong-yang Shen, Institute of Liver Transplantation, General Hospital of Chinese People’s Armed Police Forces, 69 Yongding Road, Haidian District, Beijing 100039, China. zqy47@sina.com
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Key Words |
Diabetes mellitus; Hepatocellular carcinoma; Hepatitis B virus; Liver transplantation; Survival |
Core Tip |
diabetes mellitus (DM) may be associated with hepatocellular carcinoma (HCC) pathological features, old age and poor liver function, which may influence post-liver transplantation (LT) survival in hepatitis B virus (HBV)-related HCC patients. However, no direct relation between DM and HBV infection or HBV load were observed in HCC patients. The current data represent a multi-center study involving a larger number of samples, and suggest that DM may affect the long-term post-LT survival of HBV-related HCC patients, but not of tumor recurrence. Thus, HCC patients with DM undergoing LT should be closely followed to optimize outcomes. Follow-up examinations are especially important among DM patients who are elderly or who have the presence of vascular invasion and serum α-fetoprotein levels > 2000 ng/ml pre-LT.
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Publish Date |
2016-11-18 15:13 |
Citation |
Zhang Q, Deng YL, Liu C, Huang LH, Shang L, Chen XG, Wang LT, Du JZ, Wang Y, Wang PX, Zhang H, Shen ZY. Diabetes mellitus may affect the long-term survival of hepatitis b virus-related hepatocellular carcinoma patients after liver transplantation. World J Gastroenterol 2016; 22(43): 9571-9585 |
URL |
http://www.wjgnet.com/1007-9327/full/v22/i43/9571.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v22.i43.9571 |