Publication Name	World Journal of Orthopedics
Manuscript ID	27707
Country	Greece

Received	2016-06-13 08:58
Peer-Review Started	2016-06-20 09:16
To Make the First Decision	2016-07-25 12:04
Return for Revision	2016-07-29 15:57
Revised	2016-08-21 17:46
Second Decision	2016-10-14 14:21
Accepted by Journal Editor-in-Chief	2016-10-17 22:42
Accepted by Executive Editor-in-Chief	2016-10-27 17:19
Articles in Press	2016-10-27 17:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-12-29 13:54
Publish the Manuscript Online	2017-01-10 16:10

ISSN	2218-5836 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Orthopedics
Manuscript Type	Retrospective Study
Article Title	Heterotopic ossification after the use of recombinant human bone morphogenetic protein-7
Manuscript Source	Invited Manuscript
All Author List	Marianthi Papanagiotou, Zoe H Dailiana, Theophilos Karachalios, Sokratis Varitimidis, Michael Hantes, Georgios Dimakopoulos, Marianna Vlychou and Konstantinos N Malizos
Funding Agency and Grant Number	Funding Agency Grant Number European Union (European Social Fund - ESF) Greek national funds
Corresponding Author	Zoe H Dailiana, MD, PhD, Associate Professor, Department of Orthopaedic Surgery, Faculty of Medicine, University of Thessalia, 3 Panepistimiou St, Biopolis, 41500 Larissa, Greece. dailiana@med.uth.gr
Key Words	Nonunion; Bone morphogenetic protein; Recombinant human bone morphogenetic protein-7; Heterotopic ossification; Long bone; Bone graft; Osteoinduction
Core Tip	Bone morphogenetic proteins are identified as factors promoting osteogenesis. In this study an attempt was made to estimate the rate of heterotopic bone formation in patients with long bone nonunions treated with recombinant human bone morphogenetic protein-7 (rhBMP-7), and to identify predisposing factors, related to the patient, the nonunion characteristics, and the surgical procedure. Eighteen percent of the patients developed heterotopic ossification on the radiographs, without functional limitations. All patients that deve-loped heterotopic ossification were male. This rate of heterotopic ossification after rhBMP-7 use for the treatment of long bone nonunions is higher than the rates reported in literature.
Publish Date	2017-01-10 16:10
Citation	Papanagiotou M, Dailiana ZH, Karachalios T, Varitimidis S, Hantes M, Dimakopoulos G, Vlychou M, Malizos KN. Heterotopic ossification after the use of recombinant human bone morphogenetic protein-7. World J Orthop 2017; 8(1): 36-41
URL	http://www.wjgnet.com/2218-5836/full/v8/i1/36.htm
DOI	http://dx.doi.org/10.5312/wjo.v8.i1.36

Full Article (PDF)	WJO-8-36.pdf
Full Article (Word)	WJO-8-36.doc
Manuscript File	27707-Review.docx
Answering Reviewers	27707-Answering reviewers.pdf
Audio Core Tip	27707-Audio core tip.mp3
Biostatistics Review Certificate	27707-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	27707-Conflict-of-interest statement.pdf
Copyright License Agreement	27707-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	27707-Grant application form(s).pdf
Institutional Review Board Approval Form or Document	27707-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	27707-Language certificate.pdf
Peer-review Report	27707-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	27707-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	27707-Scientific misconduct check.pdf
Scientific Editor Work List	27707-Scientific editor work list.pdf