Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	27712
Country	Germany

Received	2016-06-13 08:42
Peer-Review Started	2016-06-13 17:04
To Make the First Decision	2016-07-04 15:33
Return for Revision	2016-07-07 17:18
Revised	2016-08-30 19:38
Second Decision	2016-11-01 09:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-11-17 13:53
Articles in Press	2016-11-17 13:53
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-01-10 15:55
Publish the Manuscript Online	2017-02-03 11:25

ISSN	2219-2808 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Pediatrics
Manuscript Type	Prospective Study
Article Title	Off-label-use of sulfur-hexafluoride in voiding urosonography for diagnosis of vesicoureteral reflux in children: A survey on adverse events
Manuscript Source	Invited Manuscript
All Author List	Alexander Sauer, Clemens Wirth, Isabel Platzer, Henning Neubauer, Simon Veldhoen, Alexander Dierks, Reinhard Kaiser, Andreas Kunz, Meinrad Beer and Thorsten Bley
Funding Agency and Grant Number
Corresponding Author	Dr. Alexander Sauer, Section of Pediatric Radiology, Department of Diagnostic and Interventional Radiology, University Hospital Wuerzburg, Oberduerrbacher Straße 6, 97080 Wuerzburg, Germany. sauer_a4@ukw.de
Key Words	Voiding urosonography; Ultrasound contrast agent; Vesicoureteral reflux; SonoVue; Adverse events; Sulfur hexafluoride
Core Tip	This was a two-center study on 531 children with suspected or proven vesicoureteral reflux undergoing off-label voiding urosonography using sulfur hexafluoride (SH). We investigated the SH risk profile with intravesical administration. No acute allergic adverse event was observed with the off-label-use of SH for radiation free assessment of vesicoureteral reflux. Only a few subacute, minor-to-moderate adverse events were reported (4.1%). Hints of self-limited minor allergic reaction related to intravesical administration of sulfur hexafluoride were reported in less than 1%. This underlines the demand for an approval of SH in pediatric applications.
Publish Date	2017-02-03 11:25
Citation	Sauer A, Wirth C, Platzer I, Neubauer H, Veldhoen S, Dierks A, Kaiser R, Kunz A, Beer M, Bley T. Off-label-use of sulfur-hexa¬fluoride in voiding urosonography for diagnosis of vesicoureteral reflux in children: A survey on adverse events. World J Clin Pediatr 2017; 6(1): 52-59
URL	http://www.wjgnet.com/2219-2808/full/v6/i1/52.htm
DOI	http://dx.doi.org/10.5409/wjcp.v6.i1.52

Full Article (PDF)	WJCP-6-52.pdf
Full Article (Word)	WJCP-6-52.doc
Manuscript File	27712-Review.docx
Answering Reviewers	27712-Answering reviewers.pdf
Audio Core Tip	27712-Audio core tip.mp3
Biostatistics Review Certificate	27712-Biostatistics statement.pdf
Clinical Trial Registration Statement	27712-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	27712-Conflict-of-interest statement.pdf
Copyright License Agreement	27712-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	27712-Clinical trial registration statement.pdf
Institutional Review Board Approval Form or Document	27712-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	27712-Language certificate.pdf
Peer-review Report	27712-Peer-review(s).pdf
Scientific Misconduct Check	27712-Scientific misconduct check.pdf
Scientific Editor Work List	27712-Scientific editor work list.pdf