Publication Name	World Journal of Gastroenterology
Manuscript ID	2772
Country	China

Received	2013-03-13 10:36
Peer-Review Started	2013-03-13 21:01
To Make the First Decision	2013-04-03 09:21
Return for Revision	2013-04-11 16:15
Revised	2013-05-02 21:43
Second Decision	2013-06-19 12:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-06-20 00:57
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-07-25 11:22
Publish the Manuscript Online	2013-08-13 11:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Tumor necrosis factor-α mediates JNK activation response to intestinal ischemia-reperfusion injury
Manuscript Source	Invited Manuscript
All Author List	Qi Yang, Feng-Ping Zheng, Ya-Shi Zhan, Jin Tao, Si-Wei Tan, Hui-Ling Liu and Bin Wu
Funding Agency and Grant Number	Funding Agency Grant Number Grants-in-Aid from the Major Projects Incubator Program of the National Key Basic Research Program of China 2012CB526700 National Natural Science Foundation of China 30971357 Natural Science Foundation of Guangdong Province S2011020002348 Science and Technology Planning Project of Guangdong Province 2009B060300001 Major Projects Incubator Program of Sun Yat-Sen University 10ykjc25
Corresponding Author	Bin Wu, MD, PhD, Professor, Department of Gastroenterology, the Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou 510630, Guangdong Province, China. binwu001@hotmail.com
Key Words	Tumor necrosis factor-α; Intestine; Mucosa; Apoptosis; c-Jun N-terminal kinase
Core Tip	Ischemia-reperfusion (I/R) injury is a critical physiopathological phenomenon wherein further damage may occur when the blood supply of ischemic organs is recovered, and the mechanism of I/R remains unclear. This paper demonstrates that tumor necrosis factor-α (TNF-α) played a pivotal role in intestinal I/R injury, and pretreatment with the TNF-α inhibitor pentoxifylline or the TNF-α antibody infliximab remarkably attenuated I/R-induced injury by inhibiting TNF-α-mediated apoptosis and c-Jun N-terminal kinase (JNK) activation. The results of the study indicate there is a TNF-α-mediated JNK activation response to intestinal I/R injury.
Publish Date	2013-08-13 11:13
Citation	Yang Q, Zheng FP, Zhan YS, Tao J, Tan SW, Liu HL, Wu B. Tumor necrosis factor-α mediates JNK activation response to intestinal ischemia-reperfusion injury. World J Gastroenterol 2013; 19(30): 4925-4934
URL	http://www.wjgnet.com/1007-9327/full/v19/i30/4925.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i30.4925

Full Article (PDF)	WJG-19-4925.pdf
Manuscript File	Yang Qi-WJG-Revised.doc
Answering Reviewers	Format for Answering Reviewers.doc
Copyright License Agreement	BPG Copyright Assignment-Yang Q.pdf