Publication Name	World Journal of Stem Cells
Manuscript ID	27731
Country	Spain

Received	2016-06-15 14:38
Peer-Review Started	2016-06-17 14:10
To Make the First Decision	2016-07-27 08:20
Return for Revision	2016-07-30 19:12
Revised	2016-09-09 00:47
Second Decision	2016-11-11 17:00
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-01-14 14:23
Articles in Press	2017-01-14 14:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-02-16 13:12
Publish the Manuscript Online	2017-02-24 09:00

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cell Biology
Manuscript Type	Review
Article Title	Regulation of mitochondrial function and endoplasmic reticulum stress by nitric oxide in pluripotent stem cells
Manuscript Source	Invited Manuscript
All Author List	Estefania Caballano-Infantes, José Terron-Bautista, Amparo Beltrán-Povea, Gladys M Cahuana, Bernat Soria, Hajji Nabil, Francisco J Bedoya and Juan R Tejedo
Funding Agency and Grant Number	Funding Agency Grant Number Ministerio de Ciencia E Innovación - Bernat Soria - Innpacto Proyect IPT-2011-1615-900000 Instituto de Salud Carlos III, Gobierno de España - Bernat Soria TERCEL RD06/0010/0025 Consejeria de Salud Junta de Andalucia - Francisco Javier Bedoya Bergua PI-0105-2010 Consejeria de Economia Innovación Ciencia y Empleo - Junta de Andalucia - Francisco Javier Bedoya CTS-7127/2011
Corresponding Author	Juan R Tejedo, PhD, Andalusian Center for Molecular Biology and Regenerative Medicine-University Pablo de Olavide, Parque Científico y Tecnológico Cartuja 93, 41092 Seville, Spain. juan.tejedo@cabimer.es
Key Words	Endoplasmic reticulum stress; Mitochondrial function; Nitric oxide; Pluripotency; Cell differentiation; Mitochondrial biogenesis
Core Tip	Several studies have focused on the role of nitric oxide (NO) in regulating many physiological functions, such as metabolism and pluripotency. NO has been established to act as a potent agent for the control of stemness by promoting the expansion of pluripotent cells. NO regulates mitochondrial function and endoplasmic reticulum stress. In pluripotent stem cells, both of these factors are related to the control of cell fate and may contribute to the mechanism by which NO regulates the maintenance of pluripotency. This provides additional evidence supporting the use of NO as an alternative small molecule for the conserva-tion and expansion of cultured pluripotent cell lines necessary for implementing a cell therapy programme.
Publish Date	2017-02-24 09:00
Citation	Caballano-Infantes E, Terron-Bautista J, Beltrán-Povea A, Cahuana GM, Soria B, Nabil H, Bedoya FJ, Tejedo JR. Regulation of mito­chondrial function and endoplasmic reticulum stress by nitric oxide in pluripotent stem cells. World J Stem Cells 2017; 9(2): 26-36
URL	http://www.wjgnet.com/1948-0210/full/v9/i2/26.htm
DOI	http://dx.doi.org/10.4252/wjsc.v9.i2.26

Full Article (PDF)	WJSC-9-26.pdf
Full Article (Word)	WJSC-9-26.doc
Manuscript File	27731-Review.docx
Answering Reviewers	27731-Answering reviewers.pdf
Audio Core Tip	27731-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	27731-Conflict-of-interest statement.pdf
Copyright License Agreement	27731-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	27731-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	27731-Language certificate.pdf
Peer-review Report	27731-Peer-review(s).pdf
Scientific Misconduct Check	27731-Scientific misconduct check.pdf
Scientific Editor Work List	27731-Scientific editor work list.pdf