Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	27816
Country	United States

Received	2016-06-17 08:47
Peer-Review Started	2016-06-18 12:13
To Make the First Decision	2016-07-27 08:25
Return for Revision	2016-07-29 12:03
Revised	2016-07-30 08:11
Second Decision	2016-08-19 12:22
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-08-29 11:28
Articles in Press	2016-08-29 11:28
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-10-19 08:43
Publish the Manuscript Online	2016-10-25 16:05

ISSN	1948-9366 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Minireviews
Article Title	Goblet cell carcinoids of the appendix: Tumor biology, mutations and management strategies
Manuscript Source	Invited Manuscript
All Author List	Santosh Shenoy
Funding Agency and Grant Number
Corresponding Author	Santosh Shenoy, MD, FACS, Department of Surgery, KCVA and University of Missouri Kansas City, 4801 E Linwood Blvd, Kansas City, MO 64128, United States. shenoy2009@hotmail.com
Key Words	Goblet cell carcinoid of the appendix; Notch-1 signaling; Immunomarkers; Math-1 signaling; Intestinal stem cells; Disease management
Core Tip	Goblet cell carcinoids tumors are a distinctive group of heterogeneous appendiceal neoplasm that exhibit unique clinical and pathologic features. The pathogenesis is unclear however the tumor likely arises from pluripotent intestinal epithelial crypt base stem cells. Loss of Notch signaling may be the driver mutation with other successive downstream mutations likely favors them into progressing and behavior similar to poorly differentiated adenocarcinoma with minimal neuroendocrine differentiation. Surgery remains the main treatment modality. We discuss the clinical implications of this cancer focusing on the tumor biology, mutations, signaling mechanisms and management.
Publish Date	2016-10-25 16:05
Citation	Shenoy S. Goblet cell carcinoids of the appendix: Tumor biology, mutations and management strategies. World J Gastrointest Surg 2016; 8(10): 660-669
URL	http://www.wjgnet.com/1948-9366/full/v8/i10/660.htm
DOI	http://dx.doi.org/10.4240/wjgs.v8.i10.660

Full Article (PDF)	WJGS-8-660.pdf
Full Article (Word)	WJGS-8-660.doc
Manuscript File	27816-Review.docx
Answering Reviewers	27816-Answering reviewers.pdf
Audio Core Tip	27816-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	27816-Conflict-of-interest statement.pdf
Copyright License Agreement	27816-Copyright assignment.pdf
Peer-review Report	27816-Peer-review(s).pdf
Scientific Misconduct Check	27816-Scientific misconduct check.pdf
Scientific Editor Work List	27816-Scientific editor work list.pdf