Publication Name	World Journal of Cardiology
Manuscript ID	27900
Country	United Kingdom

Received	2016-06-21 09:26
Peer-Review Started	2016-06-24 18:25
To Make the First Decision	2016-08-05 15:22
Return for Revision	2016-08-11 15:41
Revised	2016-08-29 00:00
Second Decision	2016-10-26 16:23
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-11-02 11:20
Articles in Press	2016-11-02 11:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-01-06 17:44
Publish the Manuscript Online	2017-01-18 18:48

ISSN	1949-8462 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Review
Article Title	Endothelial progenitor cells: Exploring the pleiotropic effects of statins
Manuscript Source	Invited Manuscript
All Author List	Kully Sandhu, Mamas Mamas and Robert Butler
Funding Agency and Grant Number
Corresponding Author	Dr. Kully Sandhu, BSc, DM, MRCP, Cardiology Research Registrar, Department of Cardiology, Royal Stoke University Hospital, University Hospital of North Midlands, Stoke on Trent, Stafford ST4 6QG, United Kingdom. ksandhu@hotmail.com
Key Words	Statins; Endothelial progenitor cells; Ple­iotropic effects; Ischaemic heart disease; Pleiotropic mech­anisms
Core Tip	Statin therapy is a cornerstone of current management in coronary artery disease. Conventional thinking of stain therapy is for reduction of low-density lipoproteins. However a number of studies have observed an early benefit prior to any significant change in lipid profile. Therefore alternative pleiotropic mechanisms to account for this have been proposed. One such proposed mechanism is the ability of statins to augment both number and function of endothelial progenitor cells (EPCs). The following literature review discusses issues surrounding EPC identification, role in vascular repair, the role of statins in current medical practice and their effects on EPCs.
Publish Date	2017-01-18 18:48
Citation	Sandhu K, Mamas M, Butler R. Endothelial progenitor cells: Exploring the pleiotropic effects of statins. World J Cardiol 2017; 9(1): 1-13
URL	http://www.wjgnet.com/1949-8462/full/v9/i1/1.htm
DOI	http://dx.doi.org/10.4330/wjc.v9.i1.1

Full Article (PDF)	WJC-9-1.pdf
Full Article (Word)	WJC-9-1.doc
Manuscript File	27900-Review.docx
Answering Reviewers	27900-Answering reviewers.pdf
Audio Core Tip	27900-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	27900-Conflict-of-interest statement.pdf
Copyright License Agreement	27900-Copyright assignment.pdf
Peer-review Report	27900-Peer-review(s).pdf
Scientific Misconduct Check	27900-Scientific misconduct check.pdf
Scientific Editor Work List	27900-Scientific editor work list.pdf