Publication Name	World Journal of Hepatology
Manuscript ID	27902
Country	Argentina

Received	2016-07-13 10:10
Peer-Review Started	2016-07-14 16:47
To Make the First Decision	2016-08-22 13:50
Return for Revision	2016-08-25 17:25
Revised	2016-09-20 06:00
Second Decision	2016-09-28 11:22
Accepted by Journal Editor-in-Chief	2016-09-28 11:59
Accepted by Company Editor-in-Chief	2016-10-18 17:09
Articles in Press	2016-10-18 17:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-11-25 12:09
Publish the Manuscript Online	2016-12-06 08:34

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Prospective Study
Article Title	Prevalence and risk factors of acute-on-chronic liver failure in a single center from Argentina
Manuscript Source	Invited Manuscript
All Author List	Cristian Dominguez, Eugenia Romero, Jorgelina Graciano, Jose Luis Fernandez and Luis Viola
Funding Agency and Grant Number
Corresponding Author	Cristian Dominguez, MD, Centro Integral de Gastroenterología, Ecuador 1481 PB, Capital Federal, Buenos Aires C1425EUG, Argentina. cristian.dom@hotmail.com
Key Words	Acute-on-chronic liver failure; Acute liver decompensation; Cirrhosis; Ascites; Mortality
Core Tip	Acute-on-chronic liver failure (ACLF) is an increasingly recognized entity that is gaining acceptance in recent times. It is characterized by an acute im-pairment of an underlying chronic liver disease with high short-term mortality, produced by the development of organic failures and associated with precipitating event. However, little is known about the development and progression of this syndrome. Guided by the European Association for the Study of the Liver-Chronic Liver Failure-Consortium diagnostic criteria and the CANONIC study, we could establish that the prevalence of ACLF in our center was 29%, and that Child Pugh advanced stage, MELD score, presence of ascites and inflammation parameters were significant risk factors for ACLF.
Publish Date	2016-12-06 08:34
Citation	Dominguez C, Romero E, Graciano J, Fernandez JL, Viola L. Prevalence and risk factors of acute-on-chronic liver failure in a single center from Argentina. World J Hepatol 2016; 8(34): 1529-1534
URL	http://www.wjgnet.com/1948-5182/full/v8/i34/1529.htm
DOI	http://dx.doi.org/10.4254/wjh.v8.i34.1529

Full Article (PDF)	WJH-8-1529.pdf
Full Article (Word)	WJH-8-1529.doc
Manuscript File	27902-Review.docx
Answering Reviewers	27902-Answering reviewers.pdf
Audio Core Tip	27902-Audio core tip.mp3
Biostatistics Review Certificate	27902-Biostatistics statement.pdf
Clinical Trial Registration Statement	27902-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	27902-Conflict-of-interest statement.pdf
Copyright License Agreement	27902-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	27902-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	27902-Clinical trial registration statement.pdf
Institutional Review Board Approval Form or Document	27902-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	Editing_Certificate_20160712103443.docx
Peer-review Report	27902-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	27902-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	27902-Scientific misconduct check.pdf
Scientific Editor Work List	27902-Scientific editor work list.pdf