Publication Name	World Journal of Stem Cells
Manuscript ID	2791
Country	United States

Received	2013-03-15 09:05
Peer-Review Started	2013-03-15 20:08
To Make the First Decision	2013-04-03 09:20
Return for Revision	2013-04-12 11:24
Revised	2013-05-05 09:14
Second Decision	2013-07-05 10:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-07-05 12:17
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-09-11 13:44
Publish the Manuscript Online	2013-10-31 14:50

ISSN	1948-0210 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Engineering, Biomedical
Manuscript Type	Review
Article Title	Engineering stem cell niches in bioreactors
Manuscript Source	Invited Manuscript
All Author List	Meimei Liu, Ning Liu, Ru Zang, Yan Li and Shang-Tian Yang
Funding Agency and Grant Number
Corresponding Author	Shang-Tian Yang, PhD, Professor, William G Lowrie Department of Chemical and Biomolecular Engineering, Ohio State University, 140 west 19th Ave, Columbus, OH 43210, United States. yang.15@osu.edu
Key Words	Stem cell engineering; Bioreactor; Differentiation; Microenvironment; Microfluidics
Core Tip	Stem cells are promising cell sources for cell therapy, tissue engineering, drug discovery and disease modeling due to their ability of self-renewal and immense capability of lineage-specific differentiation. Bioreactor systems with engineered stem cell microenvironments, called “niches”, play an important role in deriving functional cell populations from stem cells. Some important factors and their effects on stem cell engineering in bioreactors are reviewed in this paper. The understanding of bioreactor regulation of stem cell niches is of great interest in developing novel biomedicines.
Publish Date	2013-10-31 14:50
Citation	Liu M, Liu N, Zang R, Li Y, Yang ST. Engineering stem cell niches in bioreactors. World J Stem Cells 2013; 5(4): 124-135
URL	http://www.wjgnet.com/1948-0210/full/v5/i4/124.htm
DOI	http://dx.doi.org/10.4252/wjsc.v5.i4.124

Full Article (PDF)	WJSC-5-124.pdf
Manuscript File	2791-Review.doc
Answering Reviewers	2791-Answering reviewers.pdf
Copyright License Agreement	2791-Copyright assignment.pdf
Peer-review Report	2791-Peer review(s).pdf
Scientific Editor Work List	2791-Scientific editor work list.doc