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12/27/2016 8:31:00 AM | Browse: 1382 | Download: 1394
Publication Name World Journal of Hepatology
Manuscript ID 27917
Country/Territory Japan
Received
2016-06-22 14:48
Peer-Review Started
2016-06-23 17:28
To Make the First Decision
2016-08-10 14:56
Return for Revision
2016-08-11 15:02
Revised
2016-09-13 23:44
Second Decision
2016-10-21 10:24
Accepted by Journal Editor-in-Chief
2016-10-21 14:58
Accepted by Company Editor-in-Chief
2016-11-02 16:00
Articles in Press
2016-11-02 16:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-12-19 08:34
Publish the Manuscript Online
2016-12-27 08:31
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Fractionation of gamma-glutamyltransferase in patients with nonalcoholic fatty liver disease and alcoholic liver disease
Manuscript Source Invited Manuscript
All Author List Shigeo Sueyoshi, Setsu Sawai, Mamoru Satoh, Masanori Seimiya, Kazuyuki Sogawa, Atsushi Fukumura, Mikihiro Tsutsumi and Fumio Nomura
Funding Agency and Grant Number
Corresponding Author Fumio Nomura, MD, Professor, Depart­ment of Molecular Diagnosis, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. fnomura@faculty.chiba-u.jp
Key Words Gamma-glutamyltransferase; f-GGT/t-GGT ratios; Alcoholic liver disease; Non-alcoholic fatty liver disease; Gel filtration liquid chromatography
Core Tip The aim of this study was to assess whether fractionation of serum gamma-glutamyltransferase (GGT) into four fractions by high-performance gel filtration chromatography is useful for the differential diagnosis of alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD). In patients with ALD, small-GGT (s-GGT)/total GGT (t-GGT) ratios were significantly higher and free-GGT (f-GGT)/t-GGT ratios were lower than in those in NAFLD. Consequently, there were marked differences in the s-GGT/f-GGT ratio between ALD and NAFLD. These preliminary results indicate that a large-scale study to clarify the diagnostic values of serum GGT fractionation in the differential diagnosis of ALD and NAFLD is warranted.
Publish Date 2016-12-27 08:31
Citation Sueyoshi S, Sawai S, Satoh M, Seimiya M, Sogawa K, Fukumura A, Tsutsumi M, Nomura F. Fractionation of gamma-glutamyltransferase in patients with nonalcoholic fatty liver disease and alcoholic liver disease. World J Hepatol 2016; 8(36): 1610-1616
URL http://www.wjgnet.com/1948-5182/full/v8/i36/1610.htm
DOI http://dx.doi.org/10.4254/wjh.v8.i36.1610
Full Article (PDF) WJH-8-1610.pdf
Full Article (Word) WJH-8-1610.doc
Manuscript File 27917-Review.docx
Answering Reviewers 27917-Answering reviewers.pdf
Audio Core Tip 27917-Audio core tip.mp3
Biostatistics Review Certificate 27917-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 27917-Conflict-of-interest statement.pdf
Copyright License Agreement 27917-Copyright assignment.pdf
Institutional Review Board Approval Form or Document 27917-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 27917-Language certificate.pdf
Peer-review Report 27917-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 27917-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 27917-Scientific misconduct check.pdf
Scientific Editor Work List 27917-Scientific editor work list.pdf