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Articles Published Processes
12/19/2016 8:28:00 PM | Browse: 1187 | Download: 2612
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Received |
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2016-06-23 09:10 |
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Peer-Review Started |
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2016-06-24 12:42 |
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To Make the First Decision |
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2016-08-22 15:10 |
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Return for Revision |
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2016-08-23 08:40 |
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Revised |
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2016-09-20 14:19 |
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Second Decision |
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2016-11-01 08:11 |
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Accepted by Journal Editor-in-Chief |
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2016-11-01 16:12 |
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Accepted by Executive Editor-in-Chief |
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2016-11-16 14:21 |
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Articles in Press |
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2016-11-13 15:23 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-12-13 17:56 |
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Publish the Manuscript Online |
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2016-12-19 20:29 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Aging related methylation influences the gene expression of key control genes in colorectal cancer and adenoma
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Orsolya Galamb, Alexandra Kalmár, Barbara Kinga Barták, Árpád V Patai, Katalin Leiszter, Bálint Péterfia, Barnabás Wichmann, Gábor Valcz, Gábor Veres, Zsolt Tulassay and Béla Molnár |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Research, Development and Innovation Office |
KMR-12-1-2012-0216 |
| Hungarian Scientific Research Fund |
OTKA-K111743 |
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| Corresponding Author |
Orsolya Galamb, PhD, 2nd Department of Internal Medicine, Semmelweis University, Szentkirályi str 46, H-1088 Budapest, Hungary. orsg1@yahoo.com
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| Key Words |
DNA methylation; Aging; Colorectal cancer; Adenoma; Epigenetic drift; Epigenetic clock; Secreted frizzled related protein 1 |
| Core Tip |
Several age-related DNA methylation altera-tions could be observed during colorectal cancer (CRC) formation and progression affecting the mRNA expression of certain CRC- and adenoma-related key control genes such as hypermethylated secreted frizzled related protein 1 (SFRP1), spectrin repeat containing nuclear envelope protein 1 and hypomethylated cell migration-inducing protein. For the first time significantly lower SFRP1 methylation levels were demonstrated in colonic tissue from children (under 18 years) compared to healthy adults. The main CRC-associated signal transduction pathways, such as WNT signaling and PI3K/Akt pathways are also influenced during aging.
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| Publish Date |
2016-12-19 20:29 |
| Citation |
Galamb O, Kalmár A, Barták BK, Patai ÁV, Leiszter K, Péterfia B, Wichmann B, Valcz G, Veres G, Tulassay Z, Molnár B. Aging related methylation influences the gene expression of key control genes in colorectal cancer and adenoma. World J Gastroenterol 2016; 22(47): 10325-10340 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i47/10325.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i47.10325 |
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