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Articles Published Processes
9/30/2016 5:59:00 PM | Browse: 1127 | Download: 2408
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Received |
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2016-06-23 08:51 |
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Peer-Review Started |
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2016-06-24 13:09 |
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To Make the First Decision |
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2016-08-08 09:08 |
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Return for Revision |
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2016-08-08 10:59 |
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Revised |
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2016-08-18 01:46 |
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Second Decision |
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2016-09-02 18:04 |
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Accepted by Journal Editor-in-Chief |
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2016-09-04 17:41 |
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Accepted by Executive Editor-in-Chief |
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2016-09-08 13:19 |
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Articles in Press |
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2016-09-08 13:20 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-09-27 10:07 |
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Publish the Manuscript Online |
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2016-09-30 18:06 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Childhood chronic gastritis and duodenitis: Role of altered sensory neuromediators
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ali Islek, Aygen Yilmaz, Gulsum Ozlem Elpek and Nuray Erin |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Akdeniz University Research Unit, Antalya, Turkey |
2012.01.0103.012 |
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| Corresponding Author |
Ali Islek, MD, Assistant Professor, Department of Pediatric Gastroenterology, Akdeniz University School of Medicine, Dumlupinar Bulvari, Antalya 07070,
Turkey. islekali@hotmail.com
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| Key Words |
Gastritis; Neuropeptides; Childhood; Neutral endopeptidase |
| Core Tip |
The etiology and pathogenesis of childhood gastritis are not entirely known. The lamina propria of the gastrointestinal tract includes sensory neuropeptides that regulate gastric blood flow, local inflammatory responses and healing processes. Vasoactive intestinal peptide (VIP), substance P (SP), and calcitonin gene-related peptide (CGRP) are such neuropeptides, and their roles in chronic childhood gastritis are not known. In this study, we investigated the changes in neuropeptides in childhood gastritis and duodenitis. Disturbances in the neuropeptide content in gastric mucosa may cause gastritis. On the basis of our findings, we propose that decreased levels of VIP and CGRP and increased levels of SP may contribute to pathological changes in gastric mucosa. New treatments targeting these molecules may have therapeutic and preventive effects.
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| Publish Date |
2016-09-30 18:06 |
| Citation |
Islek A, Yilmaz A, Elpek GO, Erin N. Childhood chronic gastritis and duodenitis: Role of altered sensory neuromediators. World J Gastroenterol 2016; 22(37): 8349-8360 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i37/8349.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i37.8349 |
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