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Articles Published Processes
2/4/2017 8:25:00 AM | Browse: 1147 | Download: 1782
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Received |
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2016-06-24 17:23 |
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Peer-Review Started |
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2016-06-27 17:12 |
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To Make the First Decision |
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2016-09-05 09:02 |
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Return for Revision |
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2016-09-05 15:15 |
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Revised |
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2016-09-15 13:40 |
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Second Decision |
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2016-11-17 16:41 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-11-29 08:37 |
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Articles in Press |
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2016-11-29 08:37 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-01-10 15:57 |
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Publish the Manuscript Online |
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2017-02-04 08:25 |
| ISSN |
2220-3249 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Virology |
| Manuscript Type |
Basic Study |
| Article Title |
Expression of hepatitis B virus surface antigens induces defective gonad phenotypes in Caenorhabditis elegans
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yi-Yin Chen, Li-Wei Lee, Wei-Ning Hong and Szecheng J Lo |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Chang Gung Memorial Hospital |
CMRPD1C0812 |
| Chang Gung Memorial Hospital |
CMRPD1C0813 |
| Chang Gung Memorial Hospital |
BMRP742 (to Lo SJ) |
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| Corresponding Author |
Szecheng J Lo, PhD, Professor, Department of Biomedical Science, College of Medicine, Chang Gung University, #259 Wen-Hwa 1st Road, Tao Yuan 333, Taiwan. losj@mail.cgu.edu.tw |
| Key Words |
Hepatitis B virus; Caenorhabditis elegans; Green fluorescence proteins; Endoplasmic reticulum stress; Gonad retardation; Surface antigens |
| Core Tip |
In the past, mouse and cell culture models have been used for studying the effects of hepatitis B virus antigens (HBsAg) on hosts. Both models have advantages and disadvantages in terms of economic and time concerns. In this study, we provide an alternative animal model, Caenorhabditis elegans (C. elegans), to demonstrate that SHBsAg can induce observable phenotypes which has never been reported in mouse and cell culture models. We suggest that C. elegans can serve as a new plateform for studying various viral pathogenesis. |
| Publish Date |
2017-02-04 08:25 |
| Citation |
Chen YY, Lee LW, Hong WN, Lo SJ. Expression of hepatitis B virus surface antigens induces defective gonad phenotypes in Caenorhabditis elegans. World J Virol 2017; 6(1): 17-25 |
| URL |
http://www.wjgnet.com/2220-3249/full/v6/i1/17.htm |
| DOI |
http://dx.doi.org/10.5501/wjv.v6.i1.17 |
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