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Articles Published Processes
9/30/2016 5:59:00 PM | Browse: 1217 | Download: 2287
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Received |
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2016-06-26 16:57 |
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Peer-Review Started |
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2016-06-28 21:51 |
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To Make the First Decision |
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2016-07-29 15:15 |
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Return for Revision |
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2016-07-29 19:01 |
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Revised |
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2016-08-09 20:22 |
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Second Decision |
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2016-08-17 08:00 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-08-23 17:31 |
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Articles in Press |
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2016-08-23 17:32 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-09-23 15:15 |
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Publish the Manuscript Online |
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2016-09-30 18:06 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Virology |
| Manuscript Type |
Observational Study |
| Article Title |
Impact of hepatitis C virus core mutations on the response to interferon-based treatment in chronic hepatitis C
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Camelia Sultana, Gabriela Oprişan, Monica Delia Teleman, Sorin Dinu; HepGen 88/2012 Project Team; Cristiana Oprea, Mihai Voiculescu and Simona Ruta |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| PN-II-PT-PCCA-2011-3.2 Program |
88/2012, HEPGEN |
| Romanian Ministry of Education and Research |
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| Corresponding Author |
Simona Ruta, MD, PhD, Professor, Chair of Virology, Emergent Diseases Department, Stefan S. Nicolau Institute of Virology, 285 Mihai Bravu Bvd, 030304 Bucharest, Romania. simona@simonaruta.ro
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| Key Words |
Chronic hepatitis C; Caucasian patients; Core substitutions; IL28B polymorphism; Treatment |
| Core Tip |
The high cost of the newly introduced direct acting antivirals precludes universal replacement of the suboptimal interferon-based therapy for chronic hepatitis C. Therefore, a series of host- and virus-related factors are used as prognostic markers of treatment response. In Asian patients, a newly described viral factor is represented by amino acid substitutions in the hepatitis C virus core protein at positions 70 and 91. The present study confirms that core substitutions are also found in Caucasian patients and, together with age and IL28B genotype, can be used as predictors of the outcome of interferon-based therapy.
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| Publish Date |
2016-09-30 18:06 |
| Citation |
Sultana C, Oprişan G, Teleman MD, Dinu S; HepGen 88/2012 Project Team; Oprea C, Voiculescu M, Ruta S. Impact of hepatitis C virus core mutations on the response to interferon-based treatment in chronic hepatitis C. World J Gastroenterol 2016; 22(37): 8406-8413 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i37/8406.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i37.8406 |
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