Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	28017
Country	Canada

Received	2016-06-24 17:31
Peer-Review Started	2016-06-29 08:18
To Make the First Decision	2016-08-10 14:56
Return for Revision	2016-08-11 15:41
Revised	2016-08-20 18:05
Second Decision	2016-10-21 10:25
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-11-02 16:03
Articles in Press	2016-11-02 16:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-12-28 20:28
Publish the Manuscript Online	2017-01-12 12:07

ISSN	1948-5204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Pre-treatment platelet counts as a prognostic and predictive factor in stage ii and iii rectal adenocarcinoma
Manuscript Source	Invited Manuscript
All Author List	Morgan Steele and Ioannis A Voutsadakis
Funding Agency and Grant Number	Funding Agency Grant Number Sault Ste. Marie Academic Medical Association to Voutsadakis IA
Corresponding Author	Ioannis A Voutsadakis, MD, PhD, Division of Medical Oncology, Department of Internal Medicine, Sault Area Hospital, Sault Ste Marie, Sault Ste. Marie, Ontario P6B 0A8, Canada. ivoutsadakis@nosm.ca
Key Words	Rectal cancer; platelets; prognosis; treat­ment response; neo-adjuvant; chemoradiation
Core Tip	Platelet counts may provide prognostic and treatment efficacy predictive information in various cancers. In this study, platelet number on diagnosis of stage II and III rectal cancer was evaluated in 51 patients before start of neo-adjuvant treatment. A significant difference was present between the two groups, of higher and lower platelets, regarding pathologic response to neo-adjuvant treatment. There was no significant difference in overall and progression free survival between the two platelet count groups. Pre-treatment carcinoembryonic antigen also held prognostic value in regards to treatment effect.
Publish Date	2017-01-12 12:07
Citation	Steele M, Voutsadakis IA. Pre-treatment platelet counts as a prognostic and predictive factor in stage ii and iii rectal adeno­carcinoma. World J Gastrointest Oncol 2017; 9(1): 42-49
URL	http://www.wjgnet.com/1948-5204/full/v9/i1/42.htm
DOI	http://dx.doi.org/10.4251/wjgo.v9.i1.42

Full Article (PDF)	WJGO-9-42.pdf
Full Article (Word)	WJGO-9-42.doc
Manuscript File	28017-Review.doc
Answering Reviewers	28017-Answering reviewers.pdf
Audio Core Tip	28017-Audio core tip.wma
Biostatistics Review Certificate	28017-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	28017-Conflict-of-interest statement.pdf
Copyright License Agreement	28017-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	28017-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20160624171325.docx
Institutional Review Board Approval Form or Document	28017-Institutional review board statement.pdf
Peer-review Report	28017-Peer-review(s).pdf
Scientific Misconduct Check	28017-Scientific misconduct check.pdf
Scientific Editor Work List	28017-Scientific editor work list.pdf