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Articles Published Processes
11/8/2016 8:12:00 PM | Browse: 954 | Download: 1555
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Received |
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2016-06-26 17:06 |
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Peer-Review Started |
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2016-06-27 17:25 |
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To Make the First Decision |
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2016-08-04 16:03 |
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Return for Revision |
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2016-08-05 09:01 |
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Revised |
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2016-08-09 00:00 |
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Second Decision |
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2016-08-19 09:17 |
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Accepted by Journal Editor-in-Chief |
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2016-08-21 21:49 |
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Accepted by Executive Editor-in-Chief |
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2016-08-29 11:51 |
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Articles in Press |
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2016-08-29 11:51 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-10-31 15:21 |
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Publish the Manuscript Online |
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2016-11-08 20:12 |
| ISSN |
2220-3249 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Virology |
| Manuscript Type |
Basic Study |
| Article Title |
Role of RNA secondary structure in emergence of compartment specific hepatitis B virus immune escape variants
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Sibnarayan Datta and Runu Chakravarty |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| University Grants Commission (UGC), Min. of Human Resource and Development, Govt. of India and Defence Research |
to Sibnarayan Datta |
| Indian Council of Medical Research (ICMR), Ministry of Health and Family Welfare (MoHFW) |
to Runu Chakravarty |
| Development Organization (DRDO), Min. of Defence, Govt. of India |
to Sibnarayan Datta |
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| Corresponding Author |
Sibnarayan Datta, PhD, Molecular Virology Laboratory, Defence Research, Laboratory (DRDO), Tezpur 784001, Assam, India. sndatta1978@gmail.com
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| Key Words |
Hepatitis B; Compartmentalization; Peripheral blood leukocytes; pgRNA; RNA secondary structure; G145R |
| Core Tip |
We have previously shown that, in our study population, distribution of hepatitis B virus (HBV) sub-genotypes A1 and A2 is highly biased in the serum/plasma and peripheral blood leukocyte (PBL) com-partments respectively. Analysing the predicted base pairing patterns of pregenomic RNAs (pgRNAs), specific for HBV subgenotype A1 and A2, we demonstrate that the potent immune escape mutation G145R evolves specifically in the context of HBV subgenotype A2. The PBL compartment is exposed to strong anti-HBs immunity, and thus G145R is highly advantageous for the virus to persist. This explains the exclusive pre-ponderance of subgenotype A2 in the PBL com-partment, sharply contrasting the prevalence of sub-genotype A1 in the serum/plasma.
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| Publish Date |
2016-11-08 20:12 |
| Citation |
Datta S, Chakravarty R. Role of RNA secondary structure in emergence of compartment specific hepatitis B virus immune escape variants. World J Virol 2016; 5(4): 161-169 |
| URL |
http://www.wjgnet.com/2220-3249/full/v5/i4/161.htm |
| DOI |
http://dx.doi.org/10.5501/wjv.v5.i4.161 |
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