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Articles Published Processes
11/10/2016 9:27:00 AM | Browse: 1117 | Download: 2113
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Received |
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2016-06-27 15:26 |
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Peer-Review Started |
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2016-06-28 19:19 |
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To Make the First Decision |
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2016-08-04 16:08 |
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Return for Revision |
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2016-08-05 09:31 |
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Revised |
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2016-08-18 15:29 |
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Second Decision |
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2016-08-30 12:02 |
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Accepted by Journal Editor-in-Chief |
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2016-09-02 14:09 |
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Accepted by Executive Editor-in-Chief |
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2016-09-08 16:50 |
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Articles in Press |
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2016-09-08 16:50 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-11-03 15:08 |
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Publish the Manuscript Online |
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2016-11-10 09:27 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Linagliptin alleviates fatty liver disease in diabetic db/db mice
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Svetlana V Michurina, Irina Ju Ishenko, Vadim V Klimontov, Sergey A Archipov, Natalia E Myakina, Marina A Cherepanova, Eugenii L Zavjalov, Galina V Koncevaya and Vladimir I Konenkov |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Russian Ministry of Education and Science |
14.621.21.0010, RFMEFI62114X0010 |
| Russian Ministry of Education and Science |
14.619.21.0005, RFMEFI61914X0005 |
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| Corresponding Author |
Vadim V Klimontov, MD, PhD, Professor of Medicine, Deputy Director for Science, Head of the Laboratory of Endocrinology, Laboratory of Clinical Immunogenetics, Scientific Institute of Clinical and Experimental Lymphology, Timakov Street 2, 630060 Novosibirsk, Russia. klimontov@mail.ru |
| Key Words |
Diabetes; Obesity; Non-alcoholic fatty liver disease; Dipeptidyl peptidase 4; Linagliptin |
| Core Tip |
Dipeptidyl peptidase 4 (DPP4) inhibitors are a relatively new class of hypoglycemic agents with multiple pleiotropic effects. In this study, we demonstrated that the DPP4 inhibitor linagliptin alleviates liver steatosis and diminishes structural changes in hepatic non-parenchymal compartments in db/db diabetic mice. The mechanism of the beneficial effect of linagliptin seems to be glucose-independent as no obvious hypoglycemic activity of the agent was observed in this model. The results of the study provide further evidence that linagliptin could be a promising agent for the treatment of non-alcoholic fatty liver disease in subjects with type 2 diabetes. |
| Publish Date |
2016-11-10 09:27 |
| Citation |
Michurina SV, Ishenko IJ, Klimontov VV, Archipov SA, Myakina NE, Cherepanova MA, Zavjalov EL, Koncevaya GV, Konenkov VI. Linagliptin alleviates fatty liver disease in diabetic db/db mice. World J Diabetes 2016; 7(19): 534-546 |
| URL |
http://www.wjgnet.com/1948-9358/full/v7/i19/534.htm |
| DOI |
http://dx.doi.org/10.4239/wjd.v7.i19.534 |
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