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Articles Published Processes
12/19/2016 8:28:00 PM | Browse: 1089 | Download: 1715
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Received |
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2016-06-27 14:47 |
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Peer-Review Started |
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2016-06-28 10:54 |
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To Make the First Decision |
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2016-08-29 09:18 |
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Return for Revision |
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2016-08-29 10:12 |
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Revised |
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2016-10-01 07:59 |
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Second Decision |
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2016-11-08 17:21 |
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Accepted by Journal Editor-in-Chief |
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2016-11-11 10:24 |
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Accepted by Executive Editor-in-Chief |
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2016-11-16 11:35 |
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Articles in Press |
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2016-11-16 11:35 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-12-13 13:38 |
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Publish the Manuscript Online |
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2016-12-19 20:29 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Virology |
| Manuscript Type |
Basic Study |
| Article Title |
Anti-viral role of toll like receptor 4 in hepatitis B virus infection: An in vitro study
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Dipanwita Das, Neelakshi Sarkar, Isha Sengupta, Ananya Pal, Debraj Saha, Manikankana Bandopadhyay, Chandrima Das, Jimmy Narayan, Shivram Prasad Singh and Runu Chakravarty |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Indian Council of Medical Research (ICMR) intramural project |
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| Biomolecular Assembly, Recognition and Dynamics (BARD) project |
12-R &D- SIN-5.04-0103 |
| Ramalingaswami Fellowship, Department of Biotechnology, Government of India |
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| Corresponding Author |
Dr. Runu Chakravarty, ICMR Virus Unit, Kolkata, ID and BG Hospital Campus, GB 4, Kolkata 700010, India. runugc@gmail.com
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| Key Words |
Hepatitis B virus; Toll like receptor 4; Cell cycle; Epigenetic marks; Innate immune response |
| Core Tip |
The study delves into the role of toll like receptor 4 (TLR4) in hepatitis B virus (HBV) infection. Inciting TLR4 brings about drastic changes in viral and host responses in hepatocyte niche. Stimulating TLR4 represses viral replication and alters important host gene expression. Virus induced G1/S cell cycle arrest is partially released on viral elimination which is corroborated with the expression of chief cell cycle regulators. Further, we have observed activation of epigenetic signatures H3K9Ac/H3K18Ac, on viral suppression post TLR4 activation. Thus, this work is important in perspective of the role of TLR4 during HBV infection in hepatocyte microenvironment.
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| Publish Date |
2016-12-19 20:29 |
| Citation |
Das D, Sarkar N, Sengupta I, Pal A, Saha D, Bandopadhyay M, Das C, Narayan J, Singh SP, Chakravarty R. Anti-viral role of toll like receptor 4 in hepatitis B virus infection: An in vitro study. World J Gastroenterol 2016; 22(47): 10341-10352 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i47/10341.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i47.10341 |
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