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Articles Published Processes
11/12/2016 1:33:00 PM | Browse: 1271 | Download: 2983
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Received |
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2016-06-27 11:08 |
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Peer-Review Started |
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2016-06-27 16:50 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2016-07-29 19:11 |
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Revised |
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2016-08-13 09:48 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2016-08-15 16:53 |
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Second Decision by Editor-in-Chief |
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2016-08-18 19:19 |
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Final Decision by Editorial Office Director |
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2016-08-23 17:34 |
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Articles in Press |
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2016-08-23 17:35 |
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Edit the Manuscript by Language Editor |
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2016-09-06 07:21 |
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Typeset the Manuscript |
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2016-11-09 15:18 |
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Publish the Manuscript Online |
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2016-11-12 13:34 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Basic Study |
| Article Title |
IRF5 regulates lung macrophages M2 polarization during severe acute pancreatitis in vitro
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Kang Sun, Song-Bing He, Jian-Guo Qu, Sheng-Chun Dang, Ji-Xiang Chen, Ai-Hua Gong, Rong Xie and Jian-Xin Zhang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Graduate Innovative Projects Foundation in Jiangsu Province |
1201270052 |
| The Social Development Foundation in Zhenjiang |
SH2013032 |
| The Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry |
fiftieth batch, 2015 |
| National Natural Science Foundation of China |
81672348 |
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| Corresponding Author |
Jian-Xin Zhang, MD, Professor, Department of General Surgery, The Affiliated Hospital of Jiangsu University, No. 438 Jiefang Road, Zhenjiang 212001, Jiangsu Province, China. doctorsunkang@126.com |
| Key Words |
Interferon regulatory factor 5; Macrophage polarization; Severe acute pancreatitis; SiRNA |
| Core Tip |
We investigated the role of interferon regulatory factor 5 (IRF5) in reversing polarization of lung macrophages during severe acute pancreatitis (SAP). Treatment with IRF5 specific siRNA could reverse the pancreatitis-induced activation of lung macrophages from M1 phenotype to M2 phenotype in vitro. Reduced expression of IRF5 may lead to a new therapeutic approach for SAP associated with acute lung injury. |
| Publish Date |
2016-11-12 13:34 |
| Citation |
Sun K, He SB, Qu JG, Dang SC, Chen JX, Gong AH, Xie R, Zhang JX. IRF5 regulates lung macrophages M2 polarization during severe acute pancreatitis in vitro. World J Gastroenterol 2016; 22(42): 9368-9377 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i42/9368.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i42.9368 |
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