Publication Name	World Journal of Gastroenterology
Manuscript ID	28105
Country	China

Received	2016-06-27 11:08
Peer-Review Started	2016-06-27 16:50
To Make the First Decision	2016-07-29 15:15
Return for Revision	2016-07-29 19:11
Revised	2016-08-13 09:48
Second Decision	2016-08-15 16:53
Accepted by Journal Editor-in-Chief	2016-08-18 19:19
Accepted by Executive Editor-in-Chief	2016-08-23 17:34
Articles in Press	2016-08-23 17:35
Publication Fee Transferred
Edit the Manuscript by Language Editor	2016-09-06 07:21
Typeset the Manuscript	2016-11-09 15:18
Publish the Manuscript Online	2016-11-12 13:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Infectious Diseases
Manuscript Type	Basic Study
Article Title	IRF5 regulates lung macrophages M2 polarization during severe acute pancreatitis in vitro
Manuscript Source	Invited Manuscript
All Author List	Kang Sun, Song-Bing He, Jian-Guo Qu, Sheng-Chun Dang, Ji-Xiang Chen, Ai-Hua Gong, Rong Xie and Jian-Xin Zhang
Funding Agency and Grant Number	Funding Agency Grant Number Graduate Innovative Projects Foundation in Jiangsu Province 1201270052 The Social Development Foundation in Zhenjiang SH2013032 The Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry fiftieth batch, 2015 National Natural Science Foundation of China 81672348
Corresponding Author	Jian-Xin Zhang, MD, Professor, Department of General Surgery, The Affiliated Hospital of Jiangsu University, No. 438 Jiefang Road, Zhenjiang 212001, Jiangsu Province, China. doctorsunkang@126.com
Key Words	Interferon regulatory factor 5; Macrophage polarization; Severe acute pancreatitis; SiRNA
Core Tip	We investigated the role of interferon regulatory factor 5 (IRF5) in reversing polarization of lung macrophages during severe acute pancreatitis (SAP). Treatment with IRF5 specific siRNA could reverse the pancreatitis-induced activation of lung macrophages from M1 phenotype to M2 phenotype in vitro. Reduced expression of IRF5 may lead to a new therapeutic approach for SAP associated with acute lung injury.
Publish Date	2016-11-12 13:34
Citation	Sun K, He SB, Qu JG, Dang SC, Chen JX, Gong AH, Xie R, Zhang JX. IRF5 regulates lung macrophages M2 polarization during severe acute pancreatitis in vitro. World J Gastroenterol 2016; 22(42): 9368-9377
URL	http://www.wjgnet.com/1007-9327/full/v22/i42/9368.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i42.9368

Full Article (PDF)	WJG-22-9368.pdf
Full Article (Word)	WJG-22-9368.doc
Manuscript File	28105-Review.docx
Answering Reviewers	28105-Answering reviewers.pdf
Audio Core Tip	28105-Audio core tip.wav
Biostatistics Review Certificate	28105-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	28105-Conflict-of-interest statement.pdf
Copyright License Agreement	28105-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	28105-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	28105-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	28105-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	28105-Language certificate.pdf
Peer-review Report	28105-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	28105-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	28105-Scientific misconduct check.pdf
Scientific Editor Work List	28105-Scientific editor work list.pdf