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Articles Published Processes
11/6/2016 3:43:00 PM | Browse: 889 | Download: 1373
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Received |
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2016-06-27 10:39 |
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Peer-Review Started |
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2016-06-27 15:57 |
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To Make the First Decision |
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2016-08-08 13:34 |
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Return for Revision |
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2016-08-12 11:11 |
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Revised |
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2016-08-31 00:50 |
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Second Decision |
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2016-09-21 15:47 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2016-09-28 17:50 |
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Articles in Press |
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2016-09-28 17:50 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-10-26 14:39 |
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Publish the Manuscript Online |
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2016-11-06 15:43 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Impact of IL28B and OAS gene family polymorphisms on interferon treatment response in Caucasian children chronically infected with hepatitis B virus
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Krzysztof Domagalski, Małgorzata Pawłowska, Agnieszka Zaleśna, Małgorzata Pilarczyk, Paweł Rajewski, Waldemar Halota and Andrzej Tretyn |
| Funding Agency and Grant Number |
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| Corresponding Author |
Małgorzata Pawłowska, MD, PhD, Department of Paediatric Infectious Diseases and Hepatology, Faculty of Medicine, Collegium Medicum Bydgoszcz, Nicolaus Copernicus University Torun, Floriana 12, 85-030 Bydgoszcz, Poland. mpawlowska@cm.umk.pl
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| Key Words |
Chronic hepatitis B; IL28B; OAS; Single-nucleotide polymorphisms; IFN therapy; Children |
| Core Tip |
The limited efficacy and side effects associated with IFN treatment limit its clinical use in paediatric patients with chronic hepatitis B (CHB). Therefore, pretreatment predictors are required to identify those patients at highest risk for treatment response failure. OAS and IL28B are well-known IFN-induced antiviral pathway players; however, the impact of host-related genetic variability in the IL28B and OAS genes on response rates to IFN therapy in CHB paediatric patients has not been studied. The results of our study show an association between IL28B rs12979860, OASL rs10849829 and OAS haplotypes and final IFN-treatment response in Caucasian CHB children.
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| Publish Date |
2016-11-06 15:43 |
| Citation |
Domagalski K, Pawłowska M, Zaleśna A, Pilarczyk M, Rajewski P, Halota W, Tretyn A. Impact of IL28B and OAS gene family polymorphisms on interferon treatment response in Caucasian children chronically infected with hepatitis B virus. World J Gastroenterol 2016; 22(41): 9186-9195 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i41/9186.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i41.9186 |
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