Publication Name	World Journal of Gastroenterology
Manuscript ID	28128
Country	Italy

Received	2016-06-27 09:59
Peer-Review Started	2016-06-27 15:04
First Decision by Editorial Office Director
Return for Revision	2016-08-03 08:33
Revised	2016-08-23 02:45
Publication Fee Transferred
Second Decision by Editor	2016-09-09 17:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2016-09-14 13:02
Articles in Press	2016-09-14 13:02
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-11-14 17:10
Publish the Manuscript Online	2016-11-26 18:57

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Infliximab does not increase colonic cancer risk associated to murine chronic colitis
Manuscript Source	Invited Manuscript
All Author List	Loris R Lopetuso, Valentina Petito, Tiziano Zinicola, Cristina Graziani, Viviana Gerardi, Vincenzo Arena, Maria Emiliana Caristo, Andrea Poscia, Giovanni Cammarota, Alfredo Papa, Valerio Cufino, Alessandro Sgambato, Antonio Gasbarrini and Franco Scaldaferri
Funding Agency and Grant Number	Funding Agency Grant Number Crohn’s and Colitis Foundation of America, Research Fellowship Award CON125252
Corresponding Author	Dr. Franco Scaldaferri, Gastroenterology Division, Catholic University of Sacred Heart, Largo Gemelli 8, 00168 Rome, Italy. francoscaldaferri@gmail.com
Key Words	Inflammatory bowel disease; Ulcerative colitis; Colorectal cancer; Infliximab; AOM-DSS model; Cancer on chronic colitis
Core Tip	We report our results on the potential role of Infliximab on cancer progression in AOM-DSS murine model of colorectal cancer associated to chronic colitis. AOM/DSS model was induced in C57BL/6 mice. Mice were injected with Infliximab during each DSS cycle while control mice received saline. Mice were sacrificed at week 10 and colons were analyzed macroscopically and microscopically for number of cancers and degree of inflammation. MTT assay was performed on CT26 to evaluate the potential influence of Infliximab (IFX) role on metabolic activity and proliferation. This study demonstrates that beside its well-known healing capacity, IFX does not increase proliferative cancer cells ability and colorectal cancer risk in AOM-DSS model of tumor on chronic colitis.
Publish Date	2016-11-26 18:57
Citation	Lopetuso LR, Petito V, Zinicola T, Graziani C, Gerardi V, Arena V, Caristo ME, Poscia A, Cammarota G, Papa A, Cufino V, Sgambato A, Gasbarrini A, Scaldaferri F. Infliximab does not increase colonic cancer risk associated to murine chronic colitis. World J Gastroenterol 2016; 22(44): 9727-9733
URL	http://www.wjgnet.com/1007-9327/full/v22/i44/9727.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i44.9727

Full Article (PDF)	WJG-22-9727.pdf
Full Article (Word)	WJG-22-9727.doc
Manuscript File	28128-Review.docx
Answering Reviewers	28128-Answering reviewers.pdf
Audio Core Tip	28128-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	28128-Conflict-of-interest statement.pdf
Copyright License Agreement	28128-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20160627075241.pdf
Institutional Animal Care and Use Committee Approval Form or Document	28128-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	28128-Institutional review board statement.pdf
Peer-review Report	28128-Peer-review(s).pdf
Scientific Misconduct Check	28128-Scientific misconduct check.pdf
Scientific Editor Work List	28128-Scientific editor work list.pdf