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Articles Published Processes
9/30/2016 5:59:00 PM | Browse: 1151 | Download: 2573
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Received |
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2016-06-27 17:36 |
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Peer-Review Started |
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2016-06-28 21:26 |
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To Make the First Decision |
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2016-07-29 18:54 |
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Return for Revision |
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2016-08-03 08:34 |
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Revised |
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2016-08-15 11:45 |
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Second Decision |
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2016-08-29 17:44 |
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Accepted by Journal Editor-in-Chief |
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2016-08-29 18:23 |
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Accepted by Executive Editor-in-Chief |
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2016-09-06 10:18 |
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Articles in Press |
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2016-09-06 10:18 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-09-26 17:05 |
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Publish the Manuscript Online |
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2016-09-30 18:06 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Characterisation of colonic dysplasia-like epithelial atypia in murine colitis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Sarron Randall-Demllo, Ruchira Fernando, Terry Brain, Sukhwinder Singh Sohal, Anthony L Cook, Nuri Guven, Dale Kunde, Kevin Spring and Rajaraman Eri |
| Funding Agency and Grant Number |
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| Corresponding Author |
Rajaraman Eri, DVM, PhD, School of Health Sciences, University of Tasmania, Launceston, Churchill Avenue, Launceston TAS 7250, Australia. rderi@utas.edu.au |
| Key Words |
Mice; Mucin-2; Colon; Colitis; Dysplasia; Dextran sulphate sodium |
| Core Tip |
Patients with ulcerative colitis (UC) are at increased risk of developing colonic cancer. Under-standing progression to early dysplastic change in the UC-associated inflammation in the colon required a suitable animal model. Winnie mice develop a UC-like chronic colitis and endoplasmic reticulum stress due to a Muc2 mutation encoding a misfolded mucin-2. We hypothesised that exacerbation of pre-existing chronic inflammation using colitogenic dextran sulphate sodium in a model of spontaneous colitis would induce colorectal tumourigenesis. This study demonstrated that exacerbation of colitis resulted in epithelial hyperplasia in the distal colon and crypt abnormalities resembling dysplasia. Altered expression of genes known to modify tumour growth, specifically Cav1, Ccl5, Myc and Trp53, in Muc2 mutants may predispose to early neoplastic change in the inflamed colon.
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| Publish Date |
2016-09-30 18:06 |
| Citation |
Randall-Demllo S, Fernando R, Brain T, Sohal SS, Cook AL, Guven N, Kunde D, Spring K, Eri R. Characterisation of colonic dysplasia-like epithelial atypia in murine colitis. World J Gastroenterol 2016; 22(37): 8334-8348 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i37/8334.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i37.8334 |
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