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Articles Published Processes
11/6/2016 3:43:00 PM | Browse: 1558 | Download: 3092
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Received |
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2016-06-29 11:35 |
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Peer-Review Started |
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2016-06-29 13:31 |
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To Make the First Decision |
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2016-08-08 13:34 |
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Return for Revision |
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2016-08-12 11:12 |
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Revised |
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2016-08-25 17:52 |
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Second Decision |
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2016-09-09 17:42 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-09-14 13:03 |
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Articles in Press |
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2016-09-14 13:03 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-10-31 09:03 |
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Publish the Manuscript Online |
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2016-11-06 15:43 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Altered pattern of tumor necrosis factor-alpha production in peripheral blood monocytes from Crohn's disease
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Claudia Loganes, Alessia Pin, Samuele Naviglio, Martina Girardelli, Anna Monica Bianco, Stefano Martelossi, Alberto Tommasini and Elisa Piscianz |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Maternal and Child Institute "Burlo Garofolo" |
RC 03/09 |
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| Corresponding Author |
Claudia Loganes, BSc, Department of Medicine, Surgery and Health Sciences, University of Trieste, Strada di Fiume 447, 34128 Trieste,
Italy. claudia.loganes@gmail.com
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| Key Words |
Crohn’s disease; Ulcerative colitis; Tumor necrosis factor-α; NOD2 variants; Toll like receptors; Dysbiosis; Activity index; LPS-binding protein |
| Core Tip |
Crohn’s disease (CD) is characterized by an aberrant activation of the mucosal immune system in genetically susceptible subjects, who often harbor variants in genes involved in the innate immunity. To study the integrity of innate immune response, the activity of the TLR and NOD2 pathways was investigated, measuring TNF-α expression in peripheral blood monocytes. CD monocytes showed a higher production of TNF-α, which was not clearly related to disease activity, to NOD2 genotype or to the presence of translocated bacteria (indirectly measured by serum LPS-binding protein), indicating that this TNF-α hyper-production may rely on a NOD2-independent pathway and is not due to systemic exposure to LPS.
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| Publish Date |
2016-11-06 15:43 |
| Citation |
Loganes C, Pin A, Naviglio S, Girardelli M, Bianco AM, Martelossi S, Tommasini A, Piscianz E. Altered pattern of tumor necrosis factor-alpha production in peripheral blood monocytes from Crohn’s disease. World J Gastroenterol 2016; 22(41): 9117-9126 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i41/9117.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i41.9117 |
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