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Articles Published Processes
11/6/2016 3:43:00 PM | Browse: 1059 | Download: 1845
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Received |
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2016-06-29 11:45 |
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Peer-Review Started |
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2016-06-29 13:22 |
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To Make the First Decision |
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2016-08-08 13:34 |
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Return for Revision |
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2016-08-12 11:13 |
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Revised |
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2016-08-26 02:16 |
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Second Decision |
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2016-09-21 15:47 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-09-28 17:52 |
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Articles in Press |
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2016-09-28 17:52 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-10-27 15:28 |
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Publish the Manuscript Online |
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2016-11-06 15:43 |
ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Retrospective Study |
Article Title |
Presepsin teardown - pitfalls of biomarkers in the diagnosis and prognosis of bacterial infection in cirrhosis
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Manuscript Source |
Invited Manuscript |
All Author List |
Maria Papp, Tamas Tornai, Zsuzsanna Vitalis, Istvan Tornai, David Tornai, Tamas Dinya, Andrea Sumegi and Peter Antal-Szalmas |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
János Bólyai Research Scholarship of Hungarian Academy of Sciences |
BO/00426/11 |
University of Debrecen and Research Grant of National Research |
RH/885/2013 |
Development and Innovation Office |
K115818/2015/1 |
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Corresponding Author |
Maria Papp, MD, PhD, Department of Internal Medicine, Division of Gastroenterology, University of Debrecen, Faculty of Medicine, Nagyerdei krt. 98, H-4032 Debrecen, Hungary. papp.maria@med.unideb.hu
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Key Words |
Presepsin; Cirrhosis; Bacterial infection; Organ failure; Mortality |
Core Tip |
C-reactive protein (CRP) and procalcitonin (PCT) are broadly used in clinical practice to aid early diagnosis of bacterial infections, but they have limitations in cirrhosis. Additional biomarkers with enhanced accuracy are highly needed. Presepsin is a novel biomarker of infection and sepsis, but has not been assessed in cirrhosis so far. In the present study we evaluated the diagnostic and prognostic performance of presepsin in cirrhosis-associated infections in comparison with classic acute phase proteins. Presepsin measurement enhanced diagnostic utility of CRP and reflected the severity of infections more accurately, with a similar efficacy as PCT. Advanced disease stage and renal failure limited the diagnostic accuracy. The increase in PCT level but not in presepsin concentration was an independent predictor of short-term mortality during infectious episodes.
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Publish Date |
2016-11-06 15:43 |
Citation |
Papp M, Tornai T, Vitalis Z, Tornai I, Tornai D, Dinya T, Sumegi A, Antal-Szalmas P. Presepsin teardown - pitfalls of biomarkers in the diagnosis and prognosis of bacterial infection in cirrhosis. World J Gastroenterol 2016; 22(41): 9172-9185 |
URL |
http://www.wjgnet.com/1007-9327/full/v22/i41/9172.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v22.i41.9172 |
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