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Articles Published Processes
12/26/2016 7:12:00 PM | Browse: 1184 | Download: 1822
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Received |
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2016-06-29 13:51 |
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Peer-Review Started |
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2016-06-29 16:02 |
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To Make the First Decision |
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2016-08-19 10:56 |
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Return for Revision |
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2016-08-23 10:15 |
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Revised |
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2016-09-05 23:18 |
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Second Decision |
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2016-09-30 13:01 |
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Accepted by Journal Editor-in-Chief |
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2016-09-30 13:39 |
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Accepted by Executive Editor-in-Chief |
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2016-10-10 17:26 |
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Articles in Press |
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2016-10-10 17:26 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2016-10-27 07:19 |
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Typeset the Manuscript |
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2016-12-16 11:58 |
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Publish the Manuscript Online |
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2016-12-26 19:13 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Microbiology |
| Manuscript Type |
Basic Study |
| Article Title |
Helicobacter pylori inhibits the cleavage of TRAF1 via a CagA-dependent mechanism
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiu-Kun Wan, Sheng-Ling Yuan, Yan-Chun Wang, Hao-Xia Tao, Wei Jiang, Zhang-Yan Guan, Cheng Cao and Chun-Jie Liu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ministry of Science and Technology of the People’s Republic of China and Major new drug creation |
2012ZX09301003-001-005 |
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| Corresponding Author |
Dr. Chun-Jie Liu, Professor, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Biotechnology, 20 Dongdajie Street, Fengtai District, Beijing 100071, China. liucj@nic.bmi.ac.cn |
| Key Words |
Helicobacter pylori; Tumor necrosis factor receptor-associated factor 1; CagA; Cleavage; Apoptosis |
| Core Tip |
We report our first results from a study of Helicobacter pylori (H. pylori)-mediated tumor necrosis factor receptor-associated factor 1 (TRAF1) cleavage. The impact of H. pylori infection and its virulence factors on TRAF1 cleavage were detected in the presence of an apoptosis inducer. This study demonstrates, for the first time, that the cleavage of TRAF1 and the activation of caspase-8 were significantly inhibited by H. pylori infection in the presence of an apoptosis inducer. In addition, the virulence factor CagA was mainly involved in the inhibition of TRAF1 cleavage. |
| Publish Date |
2016-12-26 19:13 |
| Citation |
Wan XK, Yuan SL, Wang YC, Tao HX, Jiang W, Guan ZY, Cao C, Liu CJ. Helicobacter pylori inhibits the cleavage of TRAF1 via a CagA-dependent mechanism. World J Gastroenterol 2016; 22(48): 10566-10574 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i48/10566.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i48.10566 |
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