Publication Name	World Journal of Gastroenterology
Manuscript ID	28315
Country	Serbia

Received	2016-06-29 16:30
Peer-Review Started	2016-06-30 09:49
To Make the First Decision	2016-07-29 18:54
Return for Revision	2016-08-03 08:39
Revised	2016-09-02 21:46
Second Decision	2016-09-09 17:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-09-14 13:03
Articles in Press	2016-09-14 13:03
Publication Fee Transferred
Edit the Manuscript by Language Editor	2016-10-09 03:07
Typeset the Manuscript	2016-11-21 00:40
Publish the Manuscript Online	2016-11-26 18:57

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Galectin-3 and IL-33/ST2 axis roles and interplay in diet-induced steatohepatitis
Manuscript Source	Invited Manuscript
All Author List	Nada Pejnovic, Ilija Jeftic, Nemanja Jovicic, Nebojsa Arsenijevic and Miodrag L Lukic
Funding Agency and Grant Number	Funding Agency Grant Number Swiss Science Foundation SCOPES, IZ73Z0_152407
Corresponding Author	Miodrag L Lukic, MD, PhD, Professor, Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia. miodrag.lukic@medf.kg.ac.rs
Key Words	Galectin-3; Liver fibrosis; Interleukin-33; ST2; Nonalcoholic steatohepatitis
Core Tip	Obesity-associated chronic low-grade inflammation (metaflammation) plays an important role in the pathogenesis of nonalcoholic steatohepatitis (NASH). Galectin-3 (Gal-3), a β-galactoside-binding protein, plays a regulatory role in metaflammation and tissue fibrosis. The Interleukin (IL)-33/ST2 pathway has a protective role in obesity and adipose tissue inflammation and promotes liver fibrosis. The characteristics of dietary-induced NASH differ in mice on different genetic backgrounds and Gal-3 and ST2 (IL-33R) knockout mice. In this report, we review current evidence on the roles of Gal-3 and the IL-33/ST2 pathway and their interplay in obesity-associated hepatic inflammation and fibrogenesis that may be of interest in the development of therapeutic interventions.
Publish Date	2016-11-26 18:57
Citation	Pejnovic N, Jeftic I, Jovicic N, Arsenijevic N, Lukic ML. Galectin-3 and IL-33/ST2 axis roles and interplay in diet-induced steatohepatitis. World J Gastroenterol 2016; 22(44): 9706-9717
URL	http://www.wjgnet.com/1007-9327/full/v22/i44/9706.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i44.9706

Full Article (PDF)	WJG-22-9706.pdf
Full Article (Word)	WJG-22-9706.doc
Manuscript File	28315-Review.doc
Answering Reviewers	28315-Answering reviewers.pdf
Audio Core Tip	28315-Audio core tip.wma
Conflict-of-Interest Disclosure Form	28315-Conflict of interest statement.pdf
Copyright License Agreement	28315-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	28315-Grant application form(s).pdf
Peer-review Report	28315-Peer-review(s).pdf
Scientific Misconduct Check	28315-Scientific misconduct check.pdf
Scientific Editor Work List	28315-Scientific editor work list.pdf