Publication Name	World Journal of Hepatology
Manuscript ID	28328
Country	France

Received	2016-06-29 16:57
Peer-Review Started	2016-06-30 08:39
To Make the First Decision	2016-08-10 14:54
Return for Revision	2016-08-11 10:01
Revised	2016-09-10 18:37
Second Decision	2016-10-13 12:15
Accepted by Journal Editor-in-Chief	2016-10-14 12:32
Accepted by Executive Editor-in-Chief	2016-11-02 10:54
Articles in Press	2016-11-02 11:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-12-23 13:57
Publish the Manuscript Online	2017-01-06 08:51

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Biochemistry & Molecular Biology
Manuscript Type	Review
Article Title	PI3K/SHIP2/PTEN pathway in cell polarity and hepatitis C virus pathogenesis
Manuscript Source	Invited Manuscript
All Author List	Aline Awad and Ama Gassama-Diagne
Funding Agency and Grant Number	Funding Agency Grant Number Agence Nationale de Recherche sur le Sida et les hépatites (ANRS, France), Ligue contre le cancer, France
Corresponding Author	Ama Gassama-Diagne, MD, Inserm Unité 1193, Hôpital Paul Brousse, 12 Avenue Paul Vaillant Couturier, 94800 Villejuif, France. ama.gassama@inserm.fr
Key Words	Hepatitis C virus; Phosphoinositide 3-kinase; SH2-containing inositol polyphosphate 5-phosphatase; Epithelial cell polarity; Phosphoinositides
Core Tip	Chronic hepatitis C virus (HCV) infection leads to liver cirrhosis and cancer. HCV infection modulates the lipid metabolism. Phosphoinositides are minor pho-spholipids that are also modified by HCV infec-tion. phosph-atidylinositol (PtdIns)(3,4,5)P3 is mainly formed by phosphoinositide 3-kinase (PI3K), and can be dephosphorylated by SH2-containing inositol polyphosphate 5-phosphatase (SHIP2) to generate PtdIns(3,4)P2. In this review, we will discuss the effects of SHIP2 and PI3K on the formation of cell polarity and how their expression and activation are modulated by HCV infection, leading to the disruption of cell polarity. This pathway is also discussed in the event of insulin resistance and nonalcoholic fatty liver disease related to HCV infection.
Publish Date	2017-01-06 08:51
Citation	Awad A, Gassama-Diagne A. PI3K/SHIP2/PTEN pathway in cell polarity and hepatitis C virus pathogenesis. World J Hepatol 2017; 9(1): 18-29
URL	http://www.wjgnet.com/1948-5182/full/v9/i1/18.htm
DOI	http://dx.doi.org/10.4254/wjh.v9.i1.18

Full Article (PDF)	WJH-9-18.pdf
Full Article (Word)	WJH-9-18.doc
Manuscript File	28328-Review.doc
Answering Reviewers	28328-Answering reviewers.pdf
Audio Core Tip	28328-Audio core tip.mp3
Copyright License Agreement	28328-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	28328-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	28328-Language certificate.pdf
Peer-review Report	28328-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	28328-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	28328-Scientific misconduct check.pdf
Scientific Editor Work List	28328-Scientific editor work list.pdf