Publication Name	World Journal of Gastroenterology
Manuscript ID	2836
Country	France

Received	2013-03-19 09:35
Peer-Review Started	2013-03-20 09:06
To Make the First Decision	2013-04-03 09:14
Return for Revision	2013-04-15 16:45
Revised	2013-05-14 20:11
Second Decision	2013-07-05 10:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-07-05 12:43
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-08-12 14:52
Publish the Manuscript Online	2013-08-27 16:46

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Somatic molecular changes and histo-pathological features of colorectal cancer in Tunisia
Manuscript Source	Invited Manuscript
All Author List	Sana Aissi, Marie Pierre Buisine, Farid Zerimech, Nadia Kourda, Amel Moussa, Mohamed Manai and Nicole Porchet
Funding Agency and Grant Number	Funding Agency Grant Number Tunisian Government (In part) to Aissi S
Corresponding Author	Sana Aissi, PhD, Centre de Recherche Jean-Pierre Aubert, INSERM U837, 1 place de Verdun, 59000 Lille cedex, France. sana.aissi@hotmail.com
Key Words	DNA mismatch repair; KRAS; TP53; Mucin 5AC
Core Tip	This study reports, for the first time in Tunisia, the value of various histo-pathologic features and somatic molecular changes [BRAF, KRAS, CTNNB1, TP53, mismatch repair (MMR) expression, microsatellite instability (MSI), MLH1 promoter methylation] in distinguishing patients with hereditary non polyposis colorectal cancer. Our results revealed that MUC5AC expression was significantly associated with the presence of MSI (46.7% vs 8.3%, P = 0.0039), MMR expression loss (46.7% vs 8.3%, P = 0.0039) and the presence of familial colorectal cancer (63% vs 23%, P = 0.039). These findings suggest that mucin 5AC expression analysis may be useful in the screening of Tunisian patients with high risk of colorectal cancer.
Publish Date	2013-08-27 16:46
Citation	Aissi S, Buisine MP, Zerimech F, Kourda N, Moussa A, Manai M, Porchet N. Somatic molecular changes and histo-pathological features of colorectal cancer in Tunisia. World J Gastroenterol 2013; 19(32): 5286-5294
URL	http://www.wjgnet.com/1007-9327/full/v19/i32/5286.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i32.5286

Full Article (PDF)	WJG-19-5286.pdf
Manuscript File	2836-Review.doc
Answering Reviewers	2836-Answering reviewers.pdf
Copyright License Agreement	2836-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	2836-Language certificate.pdf
Peer-review Report	2836-Peer reviews.pdf
Scientific Editor Work List	2836-Scientific editor work list.doc