| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Combination of two-hour post-endoscopic retrograde cholangiopancreatography amylase levels and cannulation times is useful for predicting post-endoscopic retrograde cholangiopancreatography pancreatitis
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Shiro Hayashi, Tsutomu Nishida, Hiromi Shimakoshi, Akiyoshi Shimoda, Takahiro Amano, Aya Sugimoto, Kei Takahashi, Kaori Mukai, Tokuhiro Matsubara, Masashi Yamamoto, Sachiko Nakajima, Koji Fukui and Masami Inada |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Shiro Hayashi, MD, Department of Gastroenterology and Hepatology, Toyonaka Municipal Hospital, 4-14-1 Shibahara, Toyonaka, Osaka 560-8565,
Japan. hayashishiro1976@yahoo.co.jp
|
| Key Words |
Serum amylase levels; Cannulation time; Post-endoscopic retrograde cholangiopancreatography pancreatitis; Predictor |
| Core Tip |
Serum amylase levels have a high negative predictive value (NPV; 95%-100%) and have therefore previously been used to predict post-endoscopic retro-grade cholangiopancreatography pancreatitis (PEP) to facilitate patient discharges. However, the positive predictive value (PPV) of serum amylase is highly variable (4%-62%); therefore, a more useful PEP predictor is needed. In this retrospective study, we identified useful predictive factors via multivariate analysis and the combination 2 h amylase levels and cannulation times. The 2 h amylase levels exhibited a good NPV (99%) and a poor PPV (22%) similar to those of previous reports but exhibited a sensitivity of only 86% with respect to PEP detection. However, the combined use of the above two variables increased the sensitivity to 96%; thus, this combination may enable clinicians to detect patients at high risk for PEP during the early phase of treatment.
|
| Publish Date |
2016-12-14 09:26 |
| Citation |
Hayashi S, Nishida T, Shimakoshi H, Shimoda A, Amano T, Sugimoto A, Takahashi K, Mukai K, Matsubara T, Yamamoto M, Nakajima S, Fukui K, Inada M. Combination of two-hour post-endoscopic retrograde cholangiopancreatography amylase levels and cannulation times is useful for predicting post-endoscopic retrograde cholangiopancreatography pancreatitis. World J Gastrointest Endosc 2016; 8(20): 777-784 |
| URL |
http://www.wjgnet.com/1948-5190/full/v8/i20/777.htm |
| DOI |
http://dx.doi.org/10.4253/wjge.v8.i20.777 |
