Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	28381
Country	Japan

Received	2016-06-30 17:57
Peer-Review Started	2016-07-01 18:23
First Decision by Editorial Office Director
Return for Revision	2016-08-05 11:27
Revised	2016-08-22 19:10
Publication Fee Transferred
Second Decision by Editor	2016-09-12 10:06
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2016-09-22 14:17
Articles in Press	2016-09-22 14:17
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-12-02 17:50
Publish the Manuscript Online	2016-12-14 09:26

ISSN	1948-5190 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Combination of two-hour post-endoscopic retrograde cholangiopancreatography amylase levels and cannulation times is useful for predicting post-endoscopic retrograde cholangiopancreatography pancreatitis
Manuscript Source	Invited Manuscript
All Author List	Shiro Hayashi, Tsutomu Nishida, Hiromi Shimakoshi, Akiyoshi Shimoda, Takahiro Amano, Aya Sugimoto, Kei Takahashi, Kaori Mukai, Tokuhiro Matsubara, Masashi Yamamoto, Sachiko Nakajima, Koji Fukui and Masami Inada
Funding Agency and Grant Number
Corresponding Author	Shiro Hayashi, MD, Department of Gastroenterology and Hepatology, Toyonaka Municipal Hospital, 4-14-1 Shibahara, Toyonaka, Osaka 560-8565, Japan. hayashishiro1976@yahoo.co.jp
Key Words	Serum amylase levels; Cannulation time; Post-endoscopic retrograde cholangiopancreatography pancreatitis; Predictor
Core Tip	Serum amylase levels have a high negative predictive value (NPV; 95%-100%) and have therefore previously been used to predict post-endoscopic retro-grade cholangiopancreatography pancreatitis (PEP) to facilitate patient discharges. However, the positive predictive value (PPV) of serum amylase is highly variable (4%-62%); therefore, a more useful PEP predictor is needed. In this retrospective study, we identified useful predictive factors via multivariate analysis and the combination 2 h amylase levels and cannulation times. The 2 h amylase levels exhibited a good NPV (99%) and a poor PPV (22%) similar to those of previous reports but exhibited a sensitivity of only 86% with respect to PEP detection. However, the combined use of the above two variables increased the sensitivity to 96%; thus, this combination may enable clinicians to detect patients at high risk for PEP during the early phase of treatment.
Publish Date	2016-12-14 09:26
Citation	Hayashi S, Nishida T, Shimakoshi H, Shimoda A, Amano T, Sugimoto A, Takahashi K, Mukai K, Matsubara T, Yamamoto M, Nakajima S, Fukui K, Inada M. Combination of two-hour post-endoscopic retrograde cholangiopancreatography amylase levels and cannulation times is useful for predicting post-endoscopic retrograde cholangiopancreatography pancreatitis. World J Gastrointest Endosc 2016; 8(20): 777-784
URL	http://www.wjgnet.com/1948-5190/full/v8/i20/777.htm
DOI	http://dx.doi.org/10.4253/wjge.v8.i20.777

Full Article (PDF)	WJGE-8-777.pdf
Full Article (Word)	WJGE-8-777.doc
Manuscript File	28381-Review.docx
Answering Reviewers	28381-Answering reviewers.pdf
Audio Core Tip	28381-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	28381-Conflict-of-interest statement.pdf
Copyright License Agreement	28381-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	28381-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	28381-Language certificate.pdf
Peer-review Report	28381-Peer-review(s).pdf
Scientific Misconduct Check	28381-Scientific misconduct check.pdf
Scientific Editor Work List	28381-Scientific editor work list.pdf