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Articles Published Processes
11/6/2016 3:43:00 PM | Browse: 1069 | Download: 1891
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Received |
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2016-06-29 18:30 |
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Peer-Review Started |
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2016-06-29 21:30 |
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To Make the First Decision |
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2016-07-29 18:54 |
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Return for Revision |
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2016-08-03 08:40 |
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Revised |
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2016-08-12 18:12 |
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Second Decision |
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2016-09-05 18:42 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-09-12 16:10 |
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Articles in Press |
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2016-09-12 16:10 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-11-02 11:10 |
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Publish the Manuscript Online |
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2016-11-06 15:43 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biology |
| Manuscript Type |
Basic Study |
| Article Title |
HER2-induced metastasis is mediated by AKT/JNK/EMT signaling pathway in gastric cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yiseul Choi, Young San Ko, Jin Ju Park, Youngsun Choi, Younghoon Kim, Jung-Soo Pyo, Bo Gun Jang, Douk Ho Hwang, Woo Ho Kim and Byung Lan Lee |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| SNUH Research Fund |
04-2016-0220 |
| Education and Research Encouragement Fund of Seoul National University Hospital (2015) |
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| Corresponding Author |
Byung Lan Lee, MD, PhD, Department of Anatomy, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 110-799,
South Korea. dslanat@snu.ac.kr
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| Key Words |
Gastric cancer; HER2; c-Jun N-terminal kinase; Protein kinase B; Metastatic potential |
| Core Tip |
We investigated the significance of c-Jun N-terminal kinase (JNK) and its interaction with protein kinase B (AKT) in the HER2 signaling with respect to metastatic potential of HER2-positive gastric cancer (GC). In clinical GC samples, we found positive relation-ships between HER2, JNK and AKT. Inhibition studies using HER2-positive SNU-216 and NCI-N87 GC cell lines demonstrated that positive crosstalk exists between HER2 and JNK, and that JNK is a downstream signaling molecule of AKT. In addition, JNK and AKT increased EMT and co-operatively contributed to the metastatic potential of HER2-positive GC cell lines. Thus, HER2 signaling contributes to GC metastasis through acti-vation of AKT/JNK/EMT pathway.
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| Publish Date |
2016-11-06 15:43 |
| Citation |
Choi Y, Ko YS, Park JJ, Choi Y, Kim Y, Pyo JS, Jang BG, Hwang DH, Kim WH, Lee BL. HER2-induced metastasis is mediated by AKT/JNK/EMT signaling pathway in gastric cancer. World J Gastroenterol 2016; 22(41): 9141-9153 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i41/9141.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i41.9141 |
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