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Articles Published Processes
2/12/2017 5:24:00 PM | Browse: 996 | Download: 1846
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Received |
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2016-07-01 10:15 |
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Peer-Review Started |
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2016-07-01 17:05 |
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To Make the First Decision |
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2016-08-19 10:55 |
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Return for Revision |
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2016-08-23 10:15 |
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Revised |
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2016-11-27 11:56 |
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Second Decision |
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2016-12-09 17:42 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-12-19 17:16 |
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Articles in Press |
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2016-12-19 17:16 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-02-06 10:20 |
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Publish the Manuscript Online |
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2017-02-12 17:23 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
MicroRNA-155 promotes the pathogenesis of experimental colitis by repressing SHIP-1 expression
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Zhan-Jun Lu, Jian-Jiong Wu, Wei-Liang Jiang, Jun-Hua Xiao, Kai-Zhong Tao, Lei Ma, Ping Zheng, Rong Wan and Xing-Peng Wang |
| Funding Agency and Grant Number |
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| Corresponding Author |
Xing-Peng Wang, MD, PhD, Professor, Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No 100, Haining Road, Shanghai 200080, China. richardwxp@163.com |
| Key Words |
Experimental colitis; Inflammatory bowel disease; MicroRNA-155; SHIP-1 |
| Core Tip |
Our present study identifies SHIP-1 as the functional target of microRNA-155 (miR-155) in macrophages. The up-regulation of miR-155 during colitis led to a significant decrease in SHIP-1 expression as well as a marked enhancement in cell proliferation and pro-inflammatory secretions, whereas the restoration of SHIP-1 expression partly reversed these changes. We further confirmed that antagomiR-155 treatment effectively alleviates dextran sulfate sodium-induced intestinal inflammation in mice, correlated with a significant elevation in SHIP-1 expression levels. Our findings indicate a novel mechanism by which miR-155 influences colitis progression. |
| Publish Date |
2017-02-12 17:23 |
| Citation |
Lu ZJ, Wu JJ, Jiang WL, Xiao JH, Tao KZ, Ma L, Zheng P, Wan R, Wang XP. MicroRNA-155 promotes the pathogenesis of experimental colitis by repressing SHIP-1 expression. World J Gastroenterol 2017; 23(6): 976-985 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i6/976.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i6.976 |
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