| Category |
Respiratory System |
| Manuscript Type |
Case Report |
| Article Title |
EGFR mutation identifies distant squamous cell carcinoma as metastasis from lung adenocarcinoma
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Nobuhiro Kanaji, Shuji Bandoh, Toshitetsu Hayashi, Reiji Haba, Naoki Watanabe, Tomoya Ishii, Asako Kunitomo, Takayuki Takahama, Akira Tadokoro, Osamu Imataki, Hiroaki Dobashi and Takuya Matsunaga |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Nobuhiro Kanaji, MD, PhD, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan. kanaji@med.kagawa-u.ac.jp |
| Key Words |
Non-small cell lung cancer; Adenocarcinoma; Squamous cell carcinoma; Epidermal growth factor receptor mutation; G719; Metastasis |
| Core Tip |
A tumor in the femur was identified genetically as a lung cancer metastasis. This case suggests that a matching epidermal growth factor receptor (EGFR) mutation in a distant lesion can validate a diagnosis of lung cancer metastasis, even if it differs histologically from the primary lesion. To the best of our knowledge, this is the first report showing the use of EGFR genetic analysis to identify a distant lesion as a lung cancer metastasis. In the era of molecularly-targeted treatments for non-small cell lung cancer, combined pathological diagnosis and genetic analysis could lead to more precise diagnoses and better understanding of histogenesis and more appropriate therapeutic selections. |
| Publish Date |
2013-07-18 17:49 |
| Citation |
Kanaji N, Bandoh S, Hayashi T, Haba R, Watanabe N, Ishii T, Kunitomo A, Takahama T, Tadokoro A, Imataki O, Dobashi H, Matsunaga T. EGFR mutation identifies distant squamous cell carcinoma as metastasis from lung adenocarcinoma. World J Respirol 2013; 3(2): 38-43 |
| URL |
http://www.wjgnet.com/2218-6255/full/v3/i2/38.htm |
| DOI |
http://dx.doi.org/10.5320/wjr.v3.i2.38 |
