Publication Name	World Journal of Critical Care Medicine
Manuscript ID	28421
Country	United States

Received	2016-06-30 09:00
Peer-Review Started	2016-07-01 19:24
To Make the First Decision	2016-08-04 16:26
Return for Revision	2016-08-05 11:56
Revised	2016-09-30 00:00
Second Decision	2017-01-04 16:03
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-01-14 14:02
Articles in Press	2017-01-14 14:02
Publication Fee Transferred	2017-04-06 16:49
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-04-28 10:07
Publish the Manuscript Online	2017-05-02 15:00

ISSN	2220-3141(online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Critical Care Medicine
Manuscript Type	Basic Study
Article Title	Female gonadal hormone effects on microglial activation and functional outcomes in a mouse model of moderate traumatic brain injury
Manuscript Source	Unsolicited Manuscript
All Author List	Odera Umeano, Haichen Wang, Hana Dawson, Beilei Lei, Afoma Umeano, Dawn Kernagis and Michael L James
Funding Agency and Grant Number
Corresponding Author	Michael L James, Associate Professor of Anesthesiology and Neurology, Multidisciplinary Neuroprotection Laboratories, Department of Anesthesiology, Duke University, DUMC 3094, Durham, NC 27710, United States. michael.james@duke.edu
Key Words	Traumatic brain injury; Microglia; Functional recovery; Inflammation; Sex
Core Tip	Differences in mortality, long-term neurological recovery, and markers of neuroinflammation exist between female and male mice after moderate traumatic brain injury (MTBI). Unexpectedly, ovariectomized mice have decreased long term neurological function after MTBI when compared to gonad intact male and female mice.
Publish Date	2017-05-02 15:00
Citation	Umeano O, Wang H, Dawson H, Lei B, Umeano A, Kernagis D, James ML. Female gonadal hormone effects on microglial activation and functional outcomes in a mouse model of moderate traumatic brain injury. World J Crit Care Med 2017; 6(2): 107-115
URL	http://www.wjgnet.com/2220-3141/full/v6/i2/107.htm
DOI	http://dx.doi.org/10.5492/wjccm.v6.i2.107

Full Article (PDF)	WJCCM-6-107.pdf
Full Article (Word)	WJCCM-6-107.doc
Manuscript File	28421-Review.docx
Answering Reviewers	28421-Answering reviewers.pdf
Audio Core Tip	28421-Audio core tip.mp3
Biostatistics Review Certificate	28421-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	28421-Conflict-of-interest statement.pdf
Copyright License Agreement	28421-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	Institutional_Animal_Care_and_Use_Committee_Statement_20160630073611.docx
Institutional Review Board Approval Form or Document	28421-Institutional review board statement.pdf
Peer-review Report	28421-Peer-review(s).pdf
Scientific Misconduct Check	28421-Scientific misconduct check.pdf
Scientific Editor Work List	28421-Scientific editor work list.pdf