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Articles Published Processes
12/20/2016 7:15:00 PM | Browse: 971 | Download: 1654
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Received |
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2016-06-30 15:48 |
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Peer-Review Started |
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2016-07-02 16:18 |
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To Make the First Decision |
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2016-08-04 16:26 |
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Return for Revision |
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2016-08-05 12:03 |
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Revised |
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2016-09-01 18:43 |
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Second Decision |
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2016-09-20 15:52 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2016-10-09 10:37 |
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Articles in Press |
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2016-10-09 10:37 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-12-13 12:18 |
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Publish the Manuscript Online |
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2016-12-20 19:15 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Randomized Clinical Trial |
| Article Title |
Influence of different second generation antipsychotics on the QTc interval: A pragmatic study
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Roy E Olsen, Rune A Kroken, Sigmund Bjørhovde, Kristina Aanesen, Hugo A Jørgensen, Else-Marie Løberg and Erik Johnsen |
| Funding Agency and Grant Number |
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| Corresponding Author |
Erik Johnsen, MD, PhD, Division of Psychiatry, Haukeland University Hospital, P.O. Box 1400, 5021 Bergen, Norway. erik.johnsen@helse-bergen.no
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| Key Words |
Psychosis; QTc prolongation; Antipsychotics; Clinical trial; Pragmatic design |
| Core Tip |
Antipsychotic drugs have a bad reputation of prolonging the QTc interval, and thereby possibly leading to fatal incidents of Torsade de pointes arrhythmias and sudden cardiac death. Differential propensities for QTc prolongation among second generation antipsy-chotics (SGAs) have been claimed, but lack substantial support from pragmatic studies. None of the SGAs was statistically significantly prolonging the QTc interval in the present pragmatic study, and no statistically significant differences among the drug groups were found for this outcome. Even in a situation with a substantial proportion with QTc prolongation at admittance any of the SGAs under investigation seemed to be safe choices in the present study.
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| Publish Date |
2016-12-20 19:15 |
| Citation |
Olsen RE, Kroken RA, Bjørhovde S, Aanesen K, Jørgensen HA, Løberg EM, Johnsen E. Influence of different second generation antipsychotics on the QTc interval: A pragmatic study. World J Psychiatr 2016; 6(4): 442-448 |
| URL |
http://www.wjgnet.com/2220-3206/full/v6/i4/442.htm |
| DOI |
http://dx.doi.org/10.5498/wjp.v6.i4.442 |
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