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12/20/2016 7:15:00 PM | Browse: 327 | Download: 474
Publication Name World Journal of Psychiatry
Manuscript ID 28436
Country/Territory Norway
Received
2016-06-30 15:48
Peer-Review Started
2016-07-02 16:18
To Make the First Decision
2016-08-04 16:26
Return for Revision
2016-08-05 12:03
Revised
2016-09-01 18:43
Second Decision
2016-09-20 15:52
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-10-09 10:37
Articles in Press
2016-10-09 10:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-12-13 12:18
Publish the Manuscript Online
2016-12-20 19:15
ISSN 2220-3206 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Psychiatry
Manuscript Type Randomized Clinical Trial
Article Title Influence of different second generation antipsychotics on the QTc interval: A pragmatic study
Manuscript Source Invited Manuscript
All Author List Roy E Olsen, Rune A Kroken, Sigmund Bjørhovde, Kristina Aanesen, Hugo A Jørgensen, Else-Marie Løberg and Erik Johnsen
Funding Agency and Grant Number
Corresponding author Erik Johnsen, MD, PhD, Division of Psychiatry, Haukeland University Hospital, P.O. Box 1400, 5021 Bergen, Norway. erik.johnsen@helse-bergen.no
Keywords Psychosis; QTc prolongation; Antipsychotics; Clinical trial; Pragmatic design
Core Tip Antipsychotic drugs have a bad reputation of prolonging the QTc interval, and thereby possibly leading to fatal incidents of Torsade de pointes arrhythmias and sudden cardiac death. Differential propensities for QTc prolongation among second generation antipsy-chotics (SGAs) have been claimed, but lack substantial support from pragmatic studies. None of the SGAs was statistically significantly prolonging the QTc interval in the present pragmatic study, and no statistically significant differences among the drug groups were found for this outcome. Even in a situation with a substantial proportion with QTc prolongation at admittance any of the SGAs under investigation seemed to be safe choices in the present study.
Publish Date 2016-12-20 19:15
Citation Olsen RE, Kroken RA, Bjørhovde S, Aanesen K, Jørgensen HA, Løberg EM, Johnsen E. Influence of different second generation antipsychotics on the QTc interval: A pragmatic study. World J Psychiatr 2016; 6(4): 442-448
Url http://www.wjgnet.com/2220-3206/full/v6/i4/442.htm
DOI http://dx.doi.org/10.5498/wjp.v6.i4.442
Full Article (PDF) WJP-6-442.pdf
Full Article (Word) WJP-6-442.doc
Manuscript File 28436-Review.docx
Answering Reviewers 28436-Answering reviewers.pdf
Audio Core Tip 28436-Audio core tip.m4a
Biostatistics Review Certificate 28436-Biostatistics statement.pdf
Clinical Trial Registration Statement 28436-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form 28436-Conflict-of-interest statement.pdf
Copyright License Agreement 28436-Copyright assignment.pdf
Data Sharing Statement 28436-Data sharing statement.pdf
Signed Informed Consent Form(s) or Document(s) 28436-Clinical trial registration statement.pdf
Institutional Review Board Approval Form or Document 28436-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 28436-Language certificate.pdf
Scientific Research Process 28436-Scientific research process.pdf
Peer-review Report 28436-Peer-review(s).pdf
Scientific Misconduct Check 28436-Scientific misconduct check.pdf
Scientific Editor Work List 28436-Scientific editor work list.pdf