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1/14/2017 10:42:00 AM | Browse: 494 | Download: 651
Publication Name World Journal of Gastroenterology
Manuscript ID 28458
Country/Territory Sweden
Received
2016-07-01 09:04
Peer-Review Started
2016-07-01 15:49
To Make the First Decision
2016-08-08 13:32
Return for Revision
2016-08-10 08:55
Revised
2016-10-05 05:30
Second Decision
2016-10-10 13:39
Accepted by Journal Editor-in-Chief
2016-10-11 17:29
Accepted by Company Editor-in-Chief
2016-10-19 17:15
Articles in Press
2016-10-19 17:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-01-04 22:28
Publish the Manuscript Online
2017-01-14 10:27
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Physiology
Manuscript Type Basic Study
Article Title Sex differences and effects of oestrogen in rat gastric mucosal defence
Manuscript Source Unsolicited Manuscript
All Author List Richard Shore, Håkan Björne, Yoko Omoto, Anna Siemiatkowska, Jan-Åke Gustafsson, Mats Lindblad and Lena Holm
Funding Agency and Grant Number
Corresponding author Richard Shore, MD, Function Perioperative Medicine and Intensive Care, Karolinska University Hospital, Karolinska vägen, S-17176 Stockholm, Sweden. richard.shore@karolinska.se
Keywords Sex differences; Gastric mucosal defence; Blood flow; Oestrogen; Gastric physiology; Mucus
Core Tip We report a sex difference in absolute gastric mucosal blood flow using an in vivo rat experimental model. Male rats had approximately twice as high blood flow in the gastric corpus mucosa compared to females. Moreover, relative gastric mucosal blood flow decreased during oestrogen administration in males but not in females and the permeability of the gastric mucosa increased to a higher level in females than in males after taurocholate challenge. However, mean clearance increase, mucus thickness and accumulation rate and the expression of ERα, ERβ or calcitonin gene related peptide in the gastric mucosa did not differ significantly between the sexes.
Publish Date 2017-01-14 10:27
Citation Shore R, Björne H, Omoto Y, Siemiatkowska A, Gustafsson JÅ, Lindblad M, Holm L. Sex differences and effects of oestrogen in rat gastric mucosal defence. World J Gastroenterol 2017; 23(3): 426-436
Url http://www.wjgnet.com/1007-9327/full/v23/i3/426.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i3.426
Full Article (PDF) WJG-23-426.pdf
Full Article (Word) WJG-23-426.doc
Manuscript File 28458-Review.doc
Answering Reviewers 28458-Answering reviewers.pdf
Audio Core Tip 28458-Audio core tip.mp3
Biostatistics Review Certificate 28458-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 28458-Conflict-of-interest statement.pdf
Copyright License Agreement 28458-Copyright assignment.pdf
Data Sharing Statement 28458-Data sharing statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 28458-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 28458-Institutional review board statement.pdf
Scientific Research Process 28458-Scientific research process.pdf
Supplementary Material Supplementary_Material_20160701013713.docx
Peer-review Report 28458-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 28458-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 28458-Scientific misconduct check.pdf
Scientific Editor Work List 28458-Scientific editor work list.pdf