Publication Name	World Journal of Gastroenterology
Manuscript ID	28462
Country	Argentina

Received	2016-07-01 08:53
Peer-Review Started	2016-07-01 15:20
To Make the First Decision	2016-08-08 13:32
Return for Revision	2016-08-12 11:15
Revised	2016-09-15 02:10
Second Decision	2016-10-10 13:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-10-19 17:16
Articles in Press	2016-10-19 17:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-11-09 15:23
Publish the Manuscript Online	2016-11-12 13:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Hepatic encephalopathy: Ever closer to its big bang
Manuscript Source	Invited Manuscript
All Author List	Pablo A Souto, Ariel R Marcotegui, Lisandro Orbea, Juan Skerl and Juan Carlos Perazzo
Funding Agency and Grant Number
Corresponding Author	Juan Carlos Perazzo, MD, Professor, Department of Pathology, Head of the Hepatic Encephalopathy and Portal Hypertension Research Group, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Uriburu 950 5th floor Ciudad, Buenos Aires 1053, Argentina. perazzopat@gmail.com
Key Words	Ammonia; Skeletal muscle; Minimal hepatic encephalopathy; Hyperammonemia
Core Tip	This work is a contribution to the current knowledge of hepatic encephalopathy (HE) and shows new important data about aspect less studied, as ammonia effect inducing morphological ultrastructural damage in skeletal muscle and gut. These alterations were observed in a Minimal HE model without liver damage, which suggests that the damage caused by ammonia may occur before liver failure.
Publish Date	2016-11-12 13:34
Citation	Souto PA, Marcotegui AR, Orbea L, Skerl J, Perazzo JC. Hepatic encephalopathy: Ever closer to its big bang. World J Gastroenterol 2016; 22(42): 9251-9256
URL	http://www.wjgnet.com/1007-9327/full/v22/i42/9251.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i42.9251

Full Article (PDF)	WJG-22-9251.pdf
Full Article (Word)	WJG-22-9251.doc
Manuscript File	28462-Review.doc
Answering Reviewers	28462-Answering reviewers.pdf
Audio Core Tip	28462-Audio core tip.wma
Conflict-of-Interest Disclosure Form	28462-Conflict-of-interest statement.pdf
Copyright License Agreement	28462-Copyright assignment.pdf
Peer-review Report	28462-Peer-review(s).pdf
Scientific Misconduct Check	28462-Scientific misconduct check.pdf
Scientific Editor Work List	28462-Scientific editor work list.pdf