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11/6/2016 3:43:00 PM | Browse: 510 | Download: 530
Publication Name World Journal of Gastroenterology
Manuscript ID 28479
Country of Manuscript Source Croatia
Received
2016-07-01 17:01
Peer-Review Started
2016-07-02 08:59
To Make the First Decision
2016-08-08 13:32
Return for Revision
2016-08-12 11:16
Revised
2016-08-28 03:29
Second Decision
2016-09-21 15:50
Accepted by Journal Editor-in-Chief
2016-09-22 18:36
Accepted by Company Editor-in-Chief
2016-09-28 17:58
Articles in Press
2016-09-28 17:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-11-01 16:36
Publish the Manuscript Online
2016-11-06 15:43
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Esophagogastric anastomosis in rats: Improved healing by BPC 157 and L-arginine, aggravated by L-NAME
Manuscript Source Invited Manuscript
All Author List Zeljko Djakovic, Ivka Djakovic, Vedran Cesarec, Goran Madzarac, Tomislav Becejac, Goran Zukanovic, Domagoj Drmic, Lovorka Batelja, Anita Zenko Sever, Danijela Kolenc, Alen Pajtak, Nikica Knez, Mladen Japjec, Kresimir Luetic, Dinko Stancic-Rokotov, Sven Seiwerth and Predrag Sikiric
Funding Agency and Grant Number
Funding Agency Grant Number
Ministry of Science, Education and Sports, Republic of Croatia 108-1083570-3635
Corresponding author Predrag Sikiric, MD, PhD, Professor, Departments of Pharmacology and Pathology Medical Faculty University of Zagreb, Salata 11, POB 916, 10000 Zagreb, Croatia. sikiric@mef.hr
Keywords Esophagogastric anastomosis; L-NAME; Aggravation; BPC 157; L-arginine; Curative treatment; Rats
Core Tip In rats underwent esophagogastric anas-tomosis, BPC 157 (given intraperitoneally or in drinking water) fully counteracted an otherwise serious disease course since very beginning (i.e., with BPC 157 bath blood vessels remained present at the gastric surface after anastomosis creation) and eliminated mortality. Additionally, BPC 157 treatment, along with L-NAME, nullified any effect of L-NAME that otherwise intensi-fied the regular course. Consistently, with worsening (with L-NAME administration) and amelioration (with L-arginine), either L-arginine-amelioration prevails (i.e., esophageal and gastric lesions are attenuated) or they counteract each other (L-NAME + L-arginine), an effect which is further reversed toward a marked beneficial effect with the addition of BPC 157 (L-NAME + L-arginine + BPC 157).
Publish Date 2016-11-06 15:43
Citation Djakovic Z, Djakovic I, Cesarec V, Madzarac G, Becejac T, Zukanovic G, Drmic D, Batelja L, Zenko Sever A, Kolenc D, Pajtak A, Knez N, Japjec M, Luetic K, Stancic-Rokotov D, Seiwerth S, Sikiric P. Esophagogastric anastomosis in rats: Improved healing by BPC 157 and L-arginine, aggravated by L-NAME. World J Gastroenterol 2016; 22(41): 9127-9140
Url http://www.wjgnet.com/1007-9327/full/v22/i41/9127.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i41.9127
Full Article (PDF) WJG-22-9127.pdf
Full Article (Word) WJG-22-9127.doc
Manuscript File 28479-Review.docx
Answering Reviewers 28479-Answering reviewers.pdf
Audio Core Tip 28479-Audio core tip.mp3
Biostatistics Review Certificate 28479-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 28479-Conflict-of-interest statement.pdf
Copyright License Agreement 28479-Copyright assignment.pdf
Data Sharing Statement 28479-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 28479-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 28479-Language certificate.pdf
Scientific Research Process 28479-Scientific research process.pdf
Peer-review Report 28479-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 28479-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 28479-Scientific misconduct check.pdf
Scientific Editor Work List 28479-Scientific editor work list.pdf